Literature DB >> 10416057

Determination of unbound drug concentration and protein-drug binding fraction in plasma.

Z Liu1, F Li, Y Huang.   

Abstract

The aim of this work was to provide a short overview of existing methods for the determination of free drug concentration and protein-drug binding fraction in plasma. Various methods have been described in terms of principles, evaluation of methods, and applications in recent years, with an emphasis on the chromatographic method, i.e. high-performance frontal analysis (HPFA).

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Year:  1999        PMID： 10416057     DOI： 10.1002/(SICI)1099-0801(199906)13:4<262::AID-BMC832>3.0.CO;2-2

Source DB:  PubMed          Journal:  Biomed Chromatogr        ISSN： 0269-3879            Impact factor:   1.902


  5 in total

1.  Automated solid-phase microextraction and thin-film microextraction for high-throughput analysis of biological fluids and ligand-receptor binding studies.

Authors:  Dajana Vuckovic; Erasmus Cudjoe; Florin Marcel Musteata; Janusz Pawliszyn
Journal:  Nat Protoc       Date:  2010-01-07       Impact factor: 13.491

2.  Interpreting physicochemical experimental data sets.

Authors:  Nicola Colclough; Mark C Wenlock
Journal:  J Comput Aided Mol Des       Date:  2015-06-09       Impact factor: 3.686

Review 3.  Importance of relating efficacy measures to unbound drug concentrations for anti-infective agents.

Authors:  Daniel Gonzalez; Stephan Schmidt; Hartmut Derendorf
Journal:  Clin Microbiol Rev       Date:  2013-04       Impact factor: 26.132

4.  Evaluation of alternatives to warfarin as probes for Sudlow site I of human serum albumin: characterization by high-performance affinity chromatography.

Authors:  K S Joseph; Annette C Moser; Sara B G Basiaga; John E Schiel; David S Hage
Journal:  J Chromatogr A       Date:  2008-10-01       Impact factor: 4.759

5.  Analysis of free drug fractions in serum by ultrafast affinity extraction and two-dimensional affinity chromatography using α1-acid glycoprotein microcolumns.

Authors:  Cong Bi; Xiwei Zheng; David S Hage
Journal:  J Chromatogr A       Date:  2016-01-04       Impact factor: 4.759
  5 in total

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