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Literature DB >> 10408235

Anti-carcinogenic activity of Taraxacum plant. II.

M Takasaki¹, T Konoshima, H Tokuda, K Masuda, Y Arai, K Shiojima, H Ageta.

Abstract

Eleven triterpenoids (1-11) from the roots of Taraxacum japonicum (Compositae) were examined for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) induced by the tumor promoter, 12-O-tetrade-canoylphorbol-13-acetate (TPA), in Raji cells as a primary screening test for anti-tumor-promoters (cancer chemopreventive agents). Of these triterpenoids, taraxasterol (1) and taraxerol (7) exhibited significant inhibitory effects on EBV-EA induction, but the inhibitory effects of their acetates 2 and 8 were weaker than those of 1 and 7. Furthermore, 1 and 7 exhibited potent anti-tumor-promoting activity in the two-stage carcinogenesis tests of mouse skin using 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a promoter, and 1 showed a remarkable inhibitory effect on mouse spontaneous mammary tumors using C3H/OuJ mouse. These results strongly suggested that taraxasterol (1) could be a valuable chemopreventive agent.

Entities: Chemical Disease Species

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Year: 1999 PMID： 10408235 DOI： 10.1248/bpb.22.606

Source DB: PubMed Journal: Biol Pharm Bull ISSN： 0918-6158 Impact factor: 2.233

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Cited

17 in total

1. Design, synthesis and experimental validation of novel potential chemopreventive agents using random forest and support vector machine binary classifiers.

Authors: Brienne Sprague; Qian Shi; Marlene T Kim; Liying Zhang; Alexander Sedykh; Eiichiro Ichiishi; Harukuni Tokuda; Kuo-Hsiung Lee; Hao Zhu
Journal: J Comput Aided Mol Des Date: 2014-05-20 Impact factor: 3.686

2. Taraxasterol suppresses the growth of human liver cancer by upregulating Hint1 expression.

Authors: Tianhao Bao; Yang Ke; Yifan Wang; Weiwei Wang; Yuehua Li; Yan Wang; Xiang Kui; Qixin Zhou; Han Zhou; Cheng Zhang; Dongming Zhou; Lin Wang; Chunjie Xiao
Journal: J Mol Med (Berl) Date: 2018-05-27 Impact factor: 4.599

3. Inhibitory effect of the flowers of artichoke (Cynara cardunculus) on TPA-induced inflammation and tumor promotion in two-stage carcinogenesis in mouse skin.

Authors: Ken Yasukawa; Hideki Matsubara; Yuri Sano
Journal: J Nat Med Date: 2010-03-12 Impact factor: 2.343

Anti-carcinogenic activity of Taraxacum plant. II.

1. Design, synthesis and experimental validation of novel potential chemopreventive agents using random forest and support vector machine binary classifiers.

2. Taraxasterol suppresses the growth of human liver cancer by upregulating Hint1 expression.

3. Inhibitory effect of the flowers of artichoke (Cynara cardunculus) on TPA-induced inflammation and tumor promotion in two-stage carcinogenesis in mouse skin.

4. Lupane triterpenes with a carbonyl group at C-20 induce cancer cell apoptosis.

5. Difference in in vitro response and esculin content in two populations of Taraxacum officinale Weber.

6. The efficacy of dandelion root extract in inducing apoptosis in drug-resistant human melanoma cells.

Review 7. Occurrence of taraxerol and taraxasterol in medicinal plants.

8. Antiproliferative Effects of Cynara cardunculus L. var. altilis (DC) Lipophilic Extracts.

9. Taraxerol Induces Cell Apoptosis through A Mitochondria-Mediated Pathway in HeLa Cells.

10. Antitumor Efficacy and Mechanism in Hepatoma H22-Bearing Mice of Brucea javanica Oil.