| Literature DB >> 10403759 |
S R Uliana1, N Goyal, E Freymüller, D F Smith.
Abstract
The meta 1 gene of Leishmania major is upregulated in metacyclic promastigotes and encodes an 11.5-kDa protein with no significant similarities to other proteins in the existing databases. In this paper, we characterize the homologous meta 1 genes in L. amazonensis and L. donovani. Proteins encoded by this gene in all three species present a high degree of identity. The meta 1 gene cannot be replaced by gene targeting in L. major, suggesting an essential role for the protein, at least in promastigotes. Overexpression of the meta 1 protein in L. amazonensis generates parasites that are more virulent than wild-type organisms in vivo. Copyright 1999 Academic Press.Entities:
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Year: 1999 PMID： 10403759 DOI： 10.1006/expr.1999.4410
Source DB: PubMed Journal: Exp Parasitol ISSN： 0014-4894 Impact factor: 2.011