Literature DB >> 10403137

Inhibition of aromatase activity by flavonoids.

H J Jeong1, Y G Shin, I H Kim, J M Pezzuto.   

Abstract

In searching for potent cancer chemopreventive agents from synthetic or natural products, 28 randomly selected flavonoids were screened for inhibitory effects against partially purified aromatase prepared from human placenta. Over 50% of the flavonoids significantly inhibited aromatase activity, with greatest activity being demonstrated with apigenin (IC50: 0.9 microg/mL), chrysin (IC50: 1.1 microg/mL), and hesperetin (IC50: 1.0 microg/mL).

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Year:  1999        PMID： 10403137     DOI： 10.1007/bf02976369

Source DB:  PubMed          Journal:  Arch Pharm Res        ISSN： 0253-6269            Impact factor:   4.946


  21 in total

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Review 9.  Botanicals and Their Bioactive Phytochemicals for Women's Health.

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10.  Pharmacophore mapping of flavone derivatives for aromatase inhibition.

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