Literature DB >> 10397496

Landomycin A inhibits DNA synthesis and G1/S cell cycle progression.

R T Crow1, B Rosenbaum, R Smith, Y Guo, K S Ramos, G A Sulikowski.   

Abstract

Landomycin A was found to inhibit the uptake of [3H]thymidine into DNA in murine smooth muscle cells indicating decreased DNA synthesis. Subsequent studies showed that landomycin A inhibits cell cycle progression.

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Year:  1999        PMID： 10397496     DOI： 10.1016/s0960-894x(99)00261-9

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  13 in total

1.  Landomycins P-W, cytotoxic angucyclines from Streptomyces cyanogenus S-136.

Authors:  Khaled A Shaaban; Sowmyalakshmi Srinivasan; Raj Kumar; Chendil Damodaran; Jürgen Rohr
Journal:  J Nat Prod       Date:  2010-12-28       Impact factor: 4.050

Review 2.  Methods for 2-Deoxyglycoside Synthesis.

Authors:  Clay S Bennett; M Carmen Galan
Journal:  Chem Rev       Date:  2018-06-28       Impact factor: 60.622

3.  Rapid generation of hydrogen peroxide contributes to the complex cell death induction by the angucycline antibiotic landomycin E.

Authors:  Rostyslav R Panchuk; Lilya V Lehka; Alessio Terenzi; Bohdan P Matselyukh; Jürgen Rohr; Amit K Jha; Theresa Downey; Iryna J Kril; Irene Herbacek; Sushilla van Schoonhoven; Petra Heffeter; Rostyslav S Stoika; Walter Berger
Journal:  Free Radic Biol Med       Date:  2017-02-09       Impact factor: 7.376

4.  Recent Advances in Transition Metal-Catalyzed Glycosylation.

Authors:  Matthew J McKay; Hien M Nguyen
Journal:  ACS Catal       Date:  2012-06-14       Impact factor: 13.084

5.  On the acceptor substrate of C-glycosyltransferase UrdGT2: three prejadomycin C-Glycosides from an engineered mutant of Streptomyces globisporus 1912 DeltalndE(urdGT2).

Authors:  Irfan Baig; Madan Kharel; Anton Kobylyanskyy; Lili Zhu; Yuriy Rebets; Bohdan Ostash; Andriy Luzhetskyy; Andreas Bechthold; Victor A Fedorenko; Jürgen Rohr
Journal:  Angew Chem Int Ed Engl       Date:  2006-11-27       Impact factor: 15.336

6.  Synthesis of the Hexasaccharide Fragment of Landomycin A Using a Mild, Reagent-Controlled Approach.

Authors:  Subbarao Yalamanchili; Dina Lloyd; Clay S Bennett
Journal:  Org Lett       Date:  2019-04-25       Impact factor: 6.005

Review 7.  Delineation of gilvocarcin, jadomycin, and landomycin pathways through combinatorial biosynthetic enzymology.

Authors:  Madan K Kharel; Jürgen Rohr
Journal:  Curr Opin Chem Biol       Date:  2012-03-30       Impact factor: 8.822

8.  Generation of new landomycins with altered saccharide patterns through over-expression of the glycosyltransferase gene lanGT3 in the biosynthetic gene cluster of landomycin A in Streptomyces cyanogenus S-136.

Authors:  Lili Zhu; Andriy Luzhetskyy; Martha Luzhetska; Cynthia Mattingly; Val Adams; Andreas Bechthold; Jürgen Rohr
Journal:  Chembiochem       Date:  2007-01-02       Impact factor: 3.164

9.  Saquayamycins G-K, cytotoxic angucyclines from Streptomyces sp. Including two analogues bearing the aminosugar rednose.

Authors:  Khaled A Shaaban; Tamer A Ahmed; Markos Leggas; Jürgen Rohr
Journal:  J Nat Prod       Date:  2012-07-03       Impact factor: 4.050

10.  11-Deoxylandomycinone and landomycins X-Z, new cytotoxic angucyclin(on)es from a Streptomyces cyanogenus K62 mutant strain.

Authors:  Khaled A Shaaban; Chris Stamatkin; Chendil Damodaran; Jürgen Rohr
Journal:  J Antibiot (Tokyo)       Date:  2010-10-27       Impact factor: 2.649
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