| Literature DB >> 10395563 |
Abstract
Recent experiments have shown directly that, in bulk chromatin, the globular domain of histone H1 is positioned close to the dyad axis and is asymmetrically disposed, consistent with a polar arrangement of H1 molecules along the nucleosome filament. In addition to a structural role, H1 may also have gene-specific effects on transcription. The positioning of a core particle relative to a transcription factor binding-site may favour either transcription factor binding or H1 binding, depending on the location of the site.Entities:
Mesh：
Substances：
Year: 1999 PMID： 10395563 DOI： 10.1016/S0955-0674(99)80042-8
Source DB: PubMed Journal: Curr Opin Cell Biol ISSN： 0955-0674 Impact factor: 8.382