Literature DB >> 10392617

Identification of rubella virus T-cell epitopes recognized in anamnestic response to RA27/3 vaccine: associations with boost in neutralizing antibody titer.

L A Mitchell1, A J Tingle, D Décarie, R Shukin.   

Abstract

Rubella virus (RV)-specific cell-mediated immunity (CMI) and antibodies were measured in healthy adolescents reimmunized with measles-mumps-rubella (MMR) vaccine. Lymphocyte proliferation to RV synthetic peptides was determined before and at 2, 4 and 10 weeks after, MMR. After MMR, increased CMI was observed with 16 peptides, including six containing antibody neutralization (NT) domains. Positive CMI (stimulation index > or =2.0) to E1(254-285) and C(1-29) before vaccination was significantly associated with a boost in NT titers, while positive CMI at weeks 2 or 4 to E1(254-285), E1(301-314), E1(389-408), E1(462-481), E2(134-150), E2(140-156), E2(168-179), C(1-29) and C(88-111) showed the same association.

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Year:  1999        PMID： 10392617     DOI： 10.1016/s0264-410x(99)00040-7

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  8 in total

1.  Relationship between HLA polymorphisms and gamma interferon and interleukin-10 cytokine production in healthy individuals after rubella vaccination.

Authors:  Inna G Ovsyannikova; Robert M Jacobson; Jenna E Ryan; Neelam Dhiman; Robert A Vierkant; Gregory A Poland
Journal:  Clin Vaccine Immunol       Date:  2007-01-10

2.  SNP/haplotype associations in cytokine and cytokine receptor genes and immunity to rubella vaccine.

Authors:  Neelam Dhiman; Iana H Haralambieva; Richard B Kennedy; Robert A Vierkant; Megan M O'Byrne; Inna G Ovsyannikova; Robert M Jacobson; Gregory A Poland
Journal:  Immunogenetics       Date:  2010-03-10       Impact factor: 2.846

3.  Predominant inflammatory cytokine secretion pattern in response to two doses of live rubella vaccine in healthy vaccinees.

Authors:  Neelam Dhiman; Iana H Haralambieva; Robert A Vierkant; V Shane Pankratz; Jenna E Ryan; Robert M Jacobson; Inna G Ovsyannikova; Gregory A Poland
Journal:  Cytokine       Date:  2010-02-01       Impact factor: 3.861

4.  Correlation between rubella antibody levels and cytokine measures of cell-mediated immunity.

Authors:  Pritish K Tosh; Richard B Kennedy; Robert A Vierkant; Robert M Jacobson; Gregory A Poland
Journal:  Viral Immunol       Date:  2009-12       Impact factor: 2.257

5.  Genetic polymorphisms associated with rubella virus-specific cellular immunity following MMR vaccination.

Authors:  Richard B Kennedy; Inna G Ovsyannikova; Iana H Haralambieva; Nathaniel D Lambert; V Shane Pankratz; Gregory A Poland
Journal:  Hum Genet       Date:  2014-08-07       Impact factor: 4.132

6.  Effect of human leukocyte antigen homozygosity on rubella vaccine-induced humoral and cell-mediated immune responses.

Authors:  Richard B Kennedy; Inna G Ovsyannikova; Robert A Vierkant; Robert M Jacobson; Gregory A Poland
Journal:  Hum Immunol       Date:  2009-11-05       Impact factor: 2.850

7.  How to determine protective immunity in the post-vaccine era.

Authors:  Carmen L Charlton; Florence Y Lai; Douglas C Dover
Journal:  Hum Vaccin Immunother       Date:  2016-04-02       Impact factor: 3.452

8.  Phylogenetic analysis of rubella virus strains from an outbreak in Madrid, Spain, from 2004 to 2005.

Authors:  A O Martínez-Torres; M M Mosquera; J C Sanz; B Ramos; J E Echevarría
Journal:  J Clin Microbiol       Date:  2008-11-19       Impact factor: 5.948
  8 in total

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