Literature DB >> 10392575

The changing landscape of ischaemic brain injury mechanisms.

J M Lee1, G J Zipfel, D W Choi.   

Abstract

Thrombolysis has become established as an acute treatment for human stroke. But despite multiple clinical trials, neuroprotective strategies have yet to be proved effective in humans. Here we discuss intrinsic tissue mechanisms of ischaemic brain injury, and present a perspective that broadening of therapeutic targeting beyond excitotoxicity and neuronal calcium overload will be desirable for developing the most effective neuroprotective therapies.

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Year:  1999        PMID： 10392575     DOI： 10.1038/399a007

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  241 in total

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Journal:  J Neurosci       Date:  2000-05-15       Impact factor: 6.167

Review 2.  A portrait of the Bcl-2 protein family: life, death, and the whole picture.

Authors:  M Pellegrini; A Strasser
Journal:  J Clin Immunol       Date:  1999-11       Impact factor: 8.317

3.  Neuronal death enhanced by N-methyl-D-aspartate antagonists.

Authors:  C Ikonomidou; V Stefovska; L Turski
Journal:  Proc Natl Acad Sci U S A       Date:  2000-11-07       Impact factor: 11.205

4.  NMDA receptor-mediated Na+ signals in spines and dendrites.

Authors:  C R Rose; A Konnerth
Journal:  J Neurosci       Date:  2001-06-15       Impact factor: 6.167

5.  Remodeling of hippocampal synaptic networks by a brief anoxia-hypoglycemia.

Authors:  Pascal Jourdain; Irina Nikonenko; Stefano Alberi; Dominique Muller
Journal:  J Neurosci       Date:  2002-04-15       Impact factor: 6.167

6.  Brain tissue responses to ischemia.

Authors:  J M Lee; M C Grabb; G J Zipfel; D W Choi
Journal:  J Clin Invest       Date:  2000-09       Impact factor: 14.808

7.  Guanosine enhances glutamate uptake in brain cortical slices at normal and excitotoxic conditions.

Authors:  Marcos Emílo dos Santos Frizzo; Diogo Rizzato Lara; Alexandre de Souza Prokopiuk; Carmen Regla Vargas; Christianne Gazzana Salbego; Moacir Wajner; Diogo Onofre Souza
Journal:  Cell Mol Neurobiol       Date:  2002-06       Impact factor: 5.046

8.  N-methyl-D-aspartate and TrkB receptors protect neurons against glutamate excitotoxicity through an extracellular signal-regulated kinase pathway.

Authors:  Daming Zhu; Xuan Wu; Kenneth I Strauss; Robert H Lipsky; Zehra Qureshi; Artin Terhakopian; Antonello Novelli; Krishna Banaudha; Ann M Marini
Journal:  J Neurosci Res       Date:  2005-04-01       Impact factor: 4.164

9.  Histone deacetylase inhibitors prevent oxidative neuronal death independent of expanded polyglutamine repeats via an Sp1-dependent pathway.

Authors:  Hoon Ryu; Junghee Lee; Beatrix A Olofsson; Aziza Mwidau; Alpaslan Dedeoglu; Maria Escudero; Erik Flemington; Jane Azizkhan-Clifford; Robert J Ferrante; Rajiv R Ratan; Alpaslan Deodoglu
Journal:  Proc Natl Acad Sci U S A       Date:  2003-03-14       Impact factor: 11.205

Review 10.  Therapeutic Hypothermia and Neuroprotection in Acute Neurological Disease.

Authors:  Kota Kurisu; Jong Youl Kim; Jesung You; Midori A Yenari
Journal:  Curr Med Chem       Date:  2019       Impact factor: 4.530
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