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Literature DB >> 10383986

Mutations in catabolite control protein CcpA separating growth effects from catabolite repression.

E Küster¹, T Hilbich, M K Dahl, W Hillen.

Abstract

Carbon catabolite repression in Bacillus megaterium is mediated by the transcriptional regulator CcpA. A chromosomal deletion of ccpA eliminates catabolite repression and reduces the growth rate on glucose. We describe four single-amino-acid mutations in CcpA which separate the growth effect from catabolite repression, suggesting distinct regulatory pathways for these phenotypes.

Entities: Chemical Species

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Year: 1999 PMID： 10383986 PMCID： PMC93908

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

33 in total

1. Analysis of CcpA mutations defective in carbon catabolite repression in Bacillus megaterium.

Authors: A Kraus; W Hillen
Journal: FEMS Microbiol Lett Date: 1997-08-01 Impact factor: 2.742

2. Genetic studies of the Lac repressor. XV: 4000 single amino acid substitutions and analysis of the resulting phenotypes on the basis of the protein structure.

Authors: J Suckow; P Markiewicz; L G Kleina; J Miller; B Kisters-Woike; B Müller-Hill
Journal: J Mol Biol Date: 1996-08-30 Impact factor: 5.469

3. Catabolite repression of the Bacillus subtilis gnt operon exerted by two catabolite-responsive elements.

Authors: Y Miwa; K Nagura; S Eguchi; H Fukuda; J Deutscher; Y Fujita
Journal: Mol Microbiol Date: 1997-03 Impact factor: 3.501

4. Cooperative and non-cooperative DNA binding modes of catabolite control protein CcpA from Bacillus megaterium result from sensing two different signals.

Authors: R Gösseringer; E Küster; A Galinier; J Deutscher; W Hillen
Journal: J Mol Biol Date: 1997-03-07 Impact factor: 5.469

5. Catabolite repression mediated by the catabolite control protein CcpA in Staphylococcus xylosus.

Authors: O Egeter; R Brückner
Journal: Mol Microbiol Date: 1996-08 Impact factor: 3.501

6. Analysis of a cis-active sequence mediating catabolite repression in gram-positive bacteria.

Authors: C J Hueck; W Hillen; M H Saier
Journal: Res Microbiol Date: 1994-09 Impact factor: 3.992

7. Regulation of expression of the Lactobacillus pentosus xylAB operon.

Authors: B C Lokman; M Heerikhuisen; R J Leer; A van den Broek; Y Borsboom; S Chaillou; P W Postma; P H Pouwels
Journal: J Bacteriol Date: 1997-09 Impact factor: 3.490

8. Specificity of DNA binding activity of the Bacillus subtilis catabolite control protein CcpA.

Authors: J H Kim; Z T Guvener; J Y Cho; K C Chung; G H Chambliss
Journal: J Bacteriol Date: 1995-09 Impact factor: 3.490

9. Crystal structure of the lactose operon repressor and its complexes with DNA and inducer.

Authors: M Lewis; G Chang; N C Horton; M A Kercher; H C Pace; M A Schumacher; R G Brennan; P Lu
Journal: Science Date: 1996-03-01 Impact factor: 47.728

10. Protein kinase-dependent HPr/CcpA interaction links glycolytic activity to carbon catabolite repression in gram-positive bacteria.

Authors: J Deutscher; E Küster; U Bergstedt; V Charrier; W Hillen
Journal: Mol Microbiol Date: 1995-03 Impact factor: 3.501

5 in total

Mutations in catabolite control protein CcpA separating growth effects from catabolite repression.

1. Analysis of CcpA mutations defective in carbon catabolite repression in Bacillus megaterium.

2. Genetic studies of the Lac repressor. XV: 4000 single amino acid substitutions and analysis of the resulting phenotypes on the basis of the protein structure.

3. Catabolite repression of the Bacillus subtilis gnt operon exerted by two catabolite-responsive elements.

4. Cooperative and non-cooperative DNA binding modes of catabolite control protein CcpA from Bacillus megaterium result from sensing two different signals.

5. Catabolite repression mediated by the catabolite control protein CcpA in Staphylococcus xylosus.

6. Analysis of a cis-active sequence mediating catabolite repression in gram-positive bacteria.

7. Regulation of expression of the Lactobacillus pentosus xylAB operon.

8. Specificity of DNA binding activity of the Bacillus subtilis catabolite control protein CcpA.

9. Crystal structure of the lactose operon repressor and its complexes with DNA and inducer.

10. Protein kinase-dependent HPr/CcpA interaction links glycolytic activity to carbon catabolite repression in gram-positive bacteria.

1. Carbon catabolite repression in Lactobacillus pentosus: analysis of the ccpA region.

2. Hierarchy in pentose sugar metabolism in Clostridium acetobutylicum.

3. The functional ccpA gene is required for carbon catabolite repression in Lactobacillus plantarum.

4. Mutations in catabolite control protein CcpA showing glucose-independent regulation in Bacillus megaterium.

5. Data on publications, structural analyses, and queries used to build and utilize the AlloRep database.