| Literature DB >> 10382945 |
L Poplawska-Szczyglowska1, J Walewski, B Pienkowska-Grela, G Rymkiewicz, O Mioduszewska.
Abstract
A 68-year-old man presented with hemiparesis, lymphocytosis, and cerebral lesions on MRI. Flow cytometry of blood, bone marrow and cerebrospinal fluid showed B-CLL lymphocytes with bright CD20 expression, sIg, and absence of CD23 antigen. Fluorescence in situ hybridisation showed trisomy 12 in 50% of analysed peripheral mononuclear cells. The patient died 6 months after the diagnosis. Rapidly progressive and fatal course of the disease was consistent with known bad prognostic significance of CD20 bright expression and trisomy 12.Entities:
Mesh：
Year: 1999 PMID： 10382945 DOI： 10.1007/bf02787361
Source DB: PubMed Journal: Med Oncol ISSN： 1357-0560 Impact factor: 3.064