OBJECTIVE: To examine the incidence of raised pulmonary artery pressure and resistance in adults with isolated atrial septal defect within the oval fossa (so called secundum defect) or sinus venosus defect. DESIGN: A historical, retrospective, unrandomised study. SETTING: A tertiary referral centre. METHODS: Cardiac catheterisation was performed in all patients, with measurement of pulmonary artery pressure and resistance. Pulmonary to systemic flow ratio was calculated using the Fick principle. Pulmonary hypertension was defined as mean pulmonary artery pressure > 30 mm Hg, and increased resistance as an Rp/Rs ratio > 0.3. PATIENTS: All patients with a secundum atrial septal or sinus venosus defect who presented between July 1988 and December 1997 were enrolled in the study. RESULTS: Pulmonary artery pressure and resistance in the patients with sinus venosus defect (n = 31) was higher than in patients with atrial septal defect (n = 138). Pulmonary hypertension was present in 26% of patients with sinus venosus and in 9% of patients with atrial septal defect. The incidence of raised pulmonary vascular resistance was 16% in patients with sinus venosus and 4% in patients with atrial septal defect. The increase in resistance occurred at a younger age in sinus venosus defect than in atrial septal defect. CONCLUSIONS: Patients with sinus venosus defect have higher pulmonary pressures and resistances and develop these complications at younger age than patients with atrial septal defects. Thus they should be managed differently than patients with "simple" atrial septal defects.
OBJECTIVE: To examine the incidence of raised pulmonary artery pressure and resistance in adults with isolated atrial septal defect within the oval fossa (so called secundum defect) or sinus venosus defect. DESIGN: A historical, retrospective, unrandomised study. SETTING: A tertiary referral centre. METHODS: Cardiac catheterisation was performed in all patients, with measurement of pulmonary artery pressure and resistance. Pulmonary to systemic flow ratio was calculated using the Fick principle. Pulmonary hypertension was defined as mean pulmonary artery pressure > 30 mm Hg, and increased resistance as an Rp/Rs ratio > 0.3. PATIENTS: All patients with a secundum atrial septal or sinus venosus defect who presented between July 1988 and December 1997 were enrolled in the study. RESULTS: Pulmonary artery pressure and resistance in the patients with sinus venosus defect (n = 31) was higher than in patients with atrial septal defect (n = 138). Pulmonary hypertension was present in 26% of patients with sinus venosus and in 9% of patients with atrial septal defect. The incidence of raised pulmonary vascular resistance was 16% in patients with sinus venosus and 4% in patients with atrial septal defect. The increase in resistance occurred at a younger age in sinus venosus defect than in atrial septal defect. CONCLUSIONS:Patients with sinus venosus defect have higher pulmonary pressures and resistances and develop these complications at younger age than patients with atrial septal defects. Thus they should be managed differently than patients with "simple" atrial septal defects.
Authors: N Hirata; Y Shimazaki; T Sakakibara; S Watanabe; F Nomura; H Akamatsu; J Sasaki; S Nakano; H Matsuda Journal: Ann Nucl Med Date: 1994-05 Impact factor: 2.668
Authors: G Cherian; C B Uthaman; M Durairaj; I P Sukumar; S Krishnaswami; P S Jairaj; S John; H Krishnaswami; A Bhaktaviziam Journal: Am Heart J Date: 1983-06 Impact factor: 4.749
Authors: Eugénie Marie-Christine Riesenkampff; Boris Schmitt; Bernhard Schnackenburg; Michael Huebler; Vladimir Alexi-Meskishvili; Roland Hetzer; Felix Berger; Titus Kuehne Journal: Pediatr Cardiol Date: 2009-01-30 Impact factor: 1.655
Authors: Antonio Augusto Lopes; Robyn J Barst; Sheila Glennis Haworth; Marlene Rabinovitch; Maha Al Dabbagh; Maria Jesus Del Cerro; Dunbar Ivy; Tarek Kashour; Krishna Kumar; S Harikrishnan; Michele D'Alto; Ana Maria Thomaz; Leína Zorzanelli; Vera D Aiello; Ana Olga Mocumbi; Maria Virginia T Santana; Ahmed Nasser Galal; Hanaa Banjar; Omar Tamimi; Alexandra Heath; Patricia C Flores; Gabriel Diaz; Julio Sandoval; Shyam Kothari; Shahin Moledina; Rilvani C Gonçalves; Alessandra C Barreto; Maria Angélica Binotto; Margarida Maia; Fahad Al Habshan; Ian Adatia Journal: Pulm Circ Date: 2014-06 Impact factor: 3.017