Literature DB >> 10369754

Dynamic DNA contacts observed in the NMR structure of winged helix protein-DNA complex.

C Jin1, I Marsden, X Chen, X Liao.   

Abstract

Genesis is an HNF-3/fkh homologous protein. By using multi-dimensional NMR techniques, we have obtained the solution structure and backbone dynamics of Genesis complexed with a 17 base-pair DNA. Our results indicate that both the local folding and dynamic properties of Genesis are perturbed when it binds to the DNA site. Our data show that a conserved flexible amino acid sequence (wing 1) makes dynamic contacts to DNA in the complex and a short helix is induced by Genesis-DNA interactions. Our data indicate that, unlike the HNF-3gamma/DNA complex, a magnesium ion is not required in forming the stable Genesis-DNA complex. Copyright 1999 Academic Press.

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Year:  1999        PMID： 10369754     DOI： 10.1006/jmbi.1999.2819

Source DB:  PubMed          Journal:  J Mol Biol        ISSN： 0022-2836            Impact factor:   5.469


  30 in total

1.  Analyses of the effects that disease-causing missense mutations have on the structure and function of the winged-helix protein FOXC1.

Authors:  R A Saleem; S Banerjee-Basu; F B Berry; A D Baxevanis; M A Walter
Journal:  Am J Hum Genet       Date:  2001-03       Impact factor: 11.025

2.  The linker histone homolog Hho1p from Saccharomyces cerevisiae represents a winged helix-turn-helix fold as determined by NMR spectroscopy.

Authors:  Katsuki Ono; Osamu Kusano; Sakurako Shimotakahara; Mitsuhiro Shimizu; Toshimasa Yamazaki; Heisaburo Shindo
Journal:  Nucleic Acids Res       Date:  2003-12-15       Impact factor: 16.971

3.  Essential structural and functional determinants within the forkhead domain of FOXC1.

Authors:  R A Saleem; S Banerjee-Basu; T C Murphy; A Baxevanis; M A Walter
Journal:  Nucleic Acids Res       Date:  2004-08-06       Impact factor: 16.971

4.  Solution structure of the human HSPC280 protein.

Authors:  Jinzhong Lin; Tao Zhou; Jinfeng Wang
Journal:  Protein Sci       Date:  2011-01       Impact factor: 6.725

5.  Specific interactions of the wing domains of FOXA1 transcription factor with DNA.

Authors:  Lisa A Cirillo; Kenneth S Zaret
Journal:  J Mol Biol       Date:  2006-12-05       Impact factor: 5.469

Review 6.  In control of biology: of mice, men and Foxes.

Authors:  Patrick J E C Wijchers; J Peter H Burbach; Marten P Smidt
Journal:  Biochem J       Date:  2006-07-15       Impact factor: 3.857

7.  Cryo-electron microscopy reveals a novel DNA-binding site on the MCM helicase.

Authors:  Alessandro Costa; Gijs van Duinen; Barbara Medagli; James Chong; Nozomi Sakakibara; Zvi Kelman; Satish K Nair; Ardan Patwardhan; Silvia Onesti
Journal:  EMBO J       Date:  2008-07-24       Impact factor: 11.598

8.  Solution structure and backbone dynamics of the DNA-binding domain of FOXP1: insight into its domain swapping and DNA binding.

Authors:  Yuan-Ping Chu; Chia-Hao Chang; Jia-Hau Shiu; Yao-Tsung Chang; Chiu-Yueh Chen; Woei-Jer Chuang
Journal:  Protein Sci       Date:  2011-04-11       Impact factor: 6.725

9.  Structure of the N-terminal oligomerization domain of DnaD reveals a unique tetramerization motif and provides insights into scaffold formation.

Authors:  S Schneider; W Zhang; P Soultanas; M Paoli
Journal:  J Mol Biol       Date:  2007-12-28       Impact factor: 5.469

10.  Homozygous FOXE3 mutations cause non-syndromic, bilateral, total sclerocornea, aphakia, microphthalmia and optic disc coloboma.

Authors:  Manir Ali; Beatriz Buentello-Volante; Martin McKibbin; J Alberto Rocha-Medina; Narcis Fernandez-Fuentes; Wilson Koga-Nakamura; Aruna Ashiq; Kamron Khan; Adam P Booth; Grange Williams; Yasmin Raashid; Hussain Jafri; Aine Rice; Chris F Inglehearn; Juan Carlos Zenteno
Journal:  Mol Vis       Date:  2010-06-23       Impact factor: 2.367
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