Literature DB >> 10368044

Impact of localized radiotherapy on blood immune cells counts and function in humans.

C Belka1, H Ottinger, E Kreuzfelder, M Weinmann, M Lindemann, A Lepple-Wienhues, W Budach, H Grosse-Wilde, M Bamberg.   

Abstract

Immune cells subsets were prospectively analyzed after localized radiotherapy (LRT). LRT reduced the levels of all lymphocyte subsets, with B-cells and naive T-cells being most sensitive. Lymphocyte function was suppressed, but still within the normal range. Rapid recovery of cytotoxic T-cells/natural killer cells after LRT and the functional suppression within normal levels explains the low incidence of infections after LRT.

Entities:  

Mesh：

Year:  1999        PMID： 10368044     DOI： 10.1016/s0167-8140(98)00130-3

Source DB:  PubMed          Journal:  Radiother Oncol        ISSN： 0167-8140            Impact factor:   6.280


  44 in total

1.  Radiation enhances regulatory T cell representation.

Authors:  Evelyn L Kachikwu; Keisuke S Iwamoto; Yu-Pei Liao; John J DeMarco; Nzhde Agazaryan; James S Economou; William H McBride; Dörthe Schaue
Journal:  Int J Radiat Oncol Biol Phys       Date:  2010-11-17       Impact factor: 7.038

2.  Use of a Humanized Mouse Model System in the Validation of Human Radiation Biodosimetry Standards.

Authors:  Monica Pujol-Canadell; Erik Young; Lubomir Smilenov
Journal:  Radiat Res       Date:  2019-02-25       Impact factor: 2.841

3.  T-cell responses to survivin in cancer patients undergoing radiation therapy.

Authors:  Dörthe Schaue; Begonya Comin-Anduix; Antoni Ribas; Li Zhang; Lee Goodglick; James W Sayre; Annelies Debucquoy; Karin Haustermans; William H McBride
Journal:  Clin Cancer Res       Date:  2008-08-01       Impact factor: 12.531

4.  Acute severe lymphopenia by radiotherapy is associated with reduced overall survival in hepatocellular carcinoma.

Authors:  Hwa Kyung Byun; Nalee Kim; Sangjoon Park; Jinsil Seong
Journal:  Strahlenther Onkol       Date:  2019-04-15       Impact factor: 3.621

5.  Effects of definitive and salvage radiotherapy on the distribution of lymphocyte subpopulations in prostate cancer patients.

Authors:  Eva K Sage; Thomas E Schmid; Hans Geinitz; Mathias Gehrmann; Michael Sedelmayr; Marciana N Duma; Stephanie E Combs; Gabriele Multhoff
Journal:  Strahlenther Onkol       Date:  2017-05-12       Impact factor: 3.621

Review 6.  Immune modulatory effects of radiotherapy as basis for well-reasoned radioimmunotherapies.

Authors:  Michael Rückert; Lisa Deloch; Rainer Fietkau; Benjamin Frey; Markus Hecht; Udo S Gaipl
Journal:  Strahlenther Onkol       Date:  2018-03-02       Impact factor: 3.621

7.  Significant impairment in immune recovery after cancer treatment.

Authors:  Duck-Hee Kang; Michael T Weaver; Na-Jin Park; Barbara Smith; Traci McArdle; John Carpenter
Journal:  Nurs Res       Date:  2009 Mar-Apr       Impact factor: 2.381

8.  Irradiated fields spared Stevens-Johnson syndrome in a patient undergoing radiotherapy for bone metastases.

Authors:  Daniela Musio; Elisabetta Parisi; Francesco Dionisi; Giuseppe Parisi; Rossella Caiazzo; Nadia Bulzonetti; Miriam Lichtner; Nicola Raffetto; Vincenzo Vullo; Enzo Banelli
Journal:  Jpn J Radiol       Date:  2009-03-12       Impact factor: 2.374

9.  The etiology of treatment-related lymphopenia in patients with malignant gliomas: modeling radiation dose to circulating lymphocytes explains clinical observations and suggests methods of modifying the impact of radiation on immune cells.

Authors:  Susannah Yovino; Lawrence Kleinberg; Stuart A Grossman; Manisha Narayanan; Eric Ford
Journal:  Cancer Invest       Date:  2013-02       Impact factor: 2.176

Review 10.  Synergizing radiation therapy and immunotherapy for curing incurable cancers. Opportunities and challenges.

Authors:  James W Hodge; Chandan Guha; Jacques Neefjes; James L Gulley
Journal:  Oncology (Williston Park)       Date:  2008-08       Impact factor: 2.990
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