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Literature DB >> 10362099

Induction of matrix metalloprotease-1 gene expression by retinoic acid in the human pancreatic tumour cell line Dan-G.

Z von Marschall¹, E O Riecken, S Rosewicz.

Abstract

We have investigated the effects of retinoic acid (RA) on matrix metalloprotease-1 (MMP-1) gene expression in the human pancreatic tumour cell line Dan-G. 13-cis RA results in a time- and dose-dependent increase of MMP-1 protein concentration. These stimulatory effects were paralleled by a time- and dose-dependent increase of MMP-1 mRNA steady-state concentrations. Nuclear run-on analysis revealed that the increase of MMP-1 mRNA was partially due to an increase of MMP-1 gene transcription. In addition, 13-cis RA treatment results in an increase of MMP-1 mRNA stability. These data demonstrate that RA stimulates MMP-1 gene expression in human pancreatic carcinoma cells by transcriptional and post-transcriptional mechanisms.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 1999 PMID： 10362099 PMCID： PMC2363049 DOI： 10.1038/sj.bjc.6690446

Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640

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