Literature DB >> 10360738

Synthesis and protein kinase C binding activity of benzolactam-V7.

D Ma1, G Wang, S Wang, A P Kozikowski, N E Lewin, P M Blumberg.   

Abstract

Benzolactam-V7 (3a), a simplified analogues of (-)-indolactam-V with twist-form conformation, was synthesized and evaluated as a new protein kinase C modulator. Both 3a and its-7-substituted analogue 3c showed weak binding activity to displace PDBU binding from recombinant PKCalpha.

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Year:  1999        PMID: 10360738     DOI: 10.1016/s0960-894x(99)00207-3

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  2 in total

1.  An overview on the antileukemic potential of D-homo-aza- and respective 17beta-acetamido-steroidal alkylating esters.

Authors:  Charalambos Camoutsis; Dimitrios T P Trafalis
Journal:  Invest New Drugs       Date:  2003-02       Impact factor: 3.850

2.  Transition Metal-Free N-Arylation of Amino Acid Esters with Diaryliodonium Salts.

Authors:  Gabriella Kervefors; Leonard Kersting; Berit Olofsson
Journal:  Chemistry       Date:  2021-03-03       Impact factor: 5.236

  2 in total

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