Literature DB >> 10358778

The high-affinity IgE receptor (Fc epsilon RI): from physiology to pathology.

J P Kinet1.   

Abstract

The high affinity receptor for immunoglobulin E (designated Fc epsilon RI) is the member of the antigen (Ag) receptor superfamily responsible for linking pathogen-or allergen-specific IgEs with cellular immunologic effector functions. This review provides background information on Fc epsilon RI function combined with more detailed summaries of recent progress in understanding specific aspects of Fc epsilon RI biology and biochemistry. Topics covered include the coordination and function of the large multiprotein signaling complexes that are assembled when Fc epsilon RI and other Ag receptors are engaged, new information on human receptor structures and tissue distribution, and the role of the FcR beta chain in signaling and its potential contribution to atopic phenotypes.

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Year:  1999        PMID： 10358778     DOI： 10.1146/annurev.immunol.17.1.931

Source DB:  PubMed          Journal:  Annu Rev Immunol        ISSN： 0732-0582            Impact factor:   28.527


  278 in total

1.  Mutant RBL mast cells defective in Fc epsilon RI signaling and lipid raft biosynthesis are reconstituted by activated Rho-family GTPases.

Authors:  K A Field; J R Apgar; E Hong-Geller; R P Siraganian; B Baird; D Holowka
Journal:  Mol Biol Cell       Date:  2000-10       Impact factor: 4.138

2.  In vivo immunological function of mast cells derived from embryonic stem cells: an approach for the rapid analysis of even embryonic lethal mutations in adult mice in vivo.

Authors:  M Tsai; J Wedemeyer; S Ganiatsas; S Y Tam; L I Zon; S J Galli
Journal:  Proc Natl Acad Sci U S A       Date:  2000-08-01       Impact factor: 11.205

3.  Genome-wide detection of alternative splicing in expressed sequences of human genes.

Authors:  B Modrek; A Resch; C Grasso; C Lee
Journal:  Nucleic Acids Res       Date:  2001-07-01       Impact factor: 16.971

4.  Stable "zeta" peptides that act as potent antagonists of the high-affinity IgE receptor.

Authors:  Gerald R Nakamura; Mark E Reynolds; Yvonne M Chen; Melissa A Starovasnik; Henry B Lowman
Journal:  Proc Natl Acad Sci U S A       Date:  2002-02-05       Impact factor: 11.205

5.  Ubiquitination and degradation of Syk and ZAP-70 protein tyrosine kinases in human NK cells upon CD16 engagement.

Authors:  R Paolini; R Molfetta; M Piccoli; L Frati; A Santoni
Journal:  Proc Natl Acad Sci U S A       Date:  2001-08-07       Impact factor: 11.205

6.  Vav1 regulates phospholipase cgamma activation and calcium responses in mast cells.

Authors:  T S Manetz; C Gonzalez-Espinosa; R Arudchandran; S Xirasagar; V Tybulewicz; J Rivera
Journal:  Mol Cell Biol       Date:  2001-06       Impact factor: 4.272

Review 7.  Analyzing the roles of mast cells and basophils in host defense and other biological responses.

Authors:  Stephen J Galli; Jochen Wedemeyer; Mindy Tsai
Journal:  Int J Hematol       Date:  2002-05       Impact factor: 2.490

Review 8.  Diversity and duplicity: human FCgamma receptors in host defense and autoimmunity.

Authors:  Robert P Kimberly; Jianming Wu; Andrew W Gibson; Kaihong Su; Hongwe Qin; Xiaoli Li; Jeffrey C Edberg
Journal:  Immunol Res       Date:  2002       Impact factor: 2.829

Review 9.  Deciphering the structure and function of FcεRI/mast cell axis in the regulation of allergy and anaphylaxis: a functional genomics paradigm.

Authors:  Jayapal Manikandan; Narasimhan Kothandaraman; Manoor Prakash Hande; Peter Natesan Pushparaj
Journal:  Cell Mol Life Sci       Date:  2011-12-07       Impact factor: 9.261

Review 10.  Targeting the Fc receptor in autoimmune disease.

Authors:  Xinrui Li; Robert P Kimberly
Journal:  Expert Opin Ther Targets       Date:  2014-03       Impact factor: 6.902
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