| Literature DB >> 10354708 |
M Huber1, C D Helgason, J E Damen, M Scheid, V Duronio, L Liu, M D Ware, R K Humphries, G Krystal.
Abstract
The recently cloned, hemopoietic-specific, src homology 2 (SH2)-containing inositol phosphatase, SHIP, is rapidly gaining prominence as a potential regulator of all phosphatidylinositol (PI)-3 kinase mediated events since it has been shown both in vitro and in vivo to hydrolyze the 5' phosphate from phosphatidylinositol-3,4,5-trisphosphate (PI-3,4,5-P3). Thus SHIP, and its more widely expressed counterpart, SHIP2, could play a central role in determining PI-3,4,5-P3 and PI-3,4-P2 levels in many cell types. To explore the in vivo function of SHIP further we recently generated a SHIP knock out mouse and in this review we discuss experiments carried out with bone marrow derived mast cells (BMMCs) from these animals.Entities:
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Year: 1999 PMID： 10354708 DOI： 10.1016/s0079-6107(98)00049-2
Source DB: PubMed Journal: Prog Biophys Mol Biol ISSN： 0079-6107 Impact factor: 3.667