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Literature DB >> 21155837

Inhibitor and activator: dual functions for SHIP in immunity and cancer.

Abstract

SHIP1 is at the nexus of intracellular signaling pathways in immune cells that mediate bone marrow (BM) graft rejection, production of inflammatory and immunosuppressive cytokines, immunoregulatory cell formation, the BM niche that supports development of the immune system, and immune cancers. This review summarizes how SHIP participates in normal immune physiology or the pathologies that result when SHIP is mutated. This review also proposes that SHIP can have either inhibitory or activating roles in cell signaling that are determined by whether signaling pathways distal to PI3K are promoted by SHIP's substrate (PI(3,4,5)P(3) ) or its product (PI(3,4)P(2) ). This review also proposes the "two PIP hypothesis" that postulates that both SHIP's product and its substrate are necessary for a cancer cell to achieve and sustain a malignant state. Finally, due to the recent discovery of small molecule antagonists and agonists for SHIP, this review discusses potential therapeutic settings where chemical modulation of SHIP might be of benefit.

Entities: CellLine Chemical Disease Gene Species

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Year: 2010 PMID： 21155837 PMCID： PMC4515353 DOI： 10.1111/j.1749-6632.2010.05869.x

Source DB: PubMed Journal: Ann N Y Acad Sci ISSN： 0077-8923 Impact factor: 5.691

128 in total

1. The terminology issue for myeloid-derived suppressor cells.

Authors: Dmitry I Gabrilovich; Vincenzo Bronte; Shu-Hsia Chen; Mario P Colombo; Augusto Ochoa; Suzanne Ostrand-Rosenberg; Hans Schreiber
Journal: Cancer Res Date: 2007-01-01 Impact factor: 12.701

2. Inappropriate recruitment and activity by the Src homology region 2 domain-containing phosphatase 1 (SHP1) is responsible for receptor dominance in the SHIP-deficient NK cell.

Authors: Joseph A Wahle; Kim H T Paraiso; Robert D Kendig; Harshani R Lawrence; Liwei Chen; Jerry Wu; William G Kerr
Journal: J Immunol Date: 2007-12-15 Impact factor: 5.422

3. TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1.

Authors: Qisheng Peng; Shikha Malhotra; James A Torchia; William G Kerr; K Mark Coggeshall; Mary Beth Humphrey
Journal: Sci Signal Date: 2010-05-18 Impact factor: 8.192

4. The human SHIP gene is differentially expressed in cell lineages of the bone marrow and blood.

Authors: S J Geier; P A Algate; K Carlberg; D Flowers; C Friedman; B Trask; L R Rohrschneider
Journal: Blood Date: 1997-03-15 Impact factor: 22.113

5. SHIP1 inhibition increases immunoregulatory capacity and triggers apoptosis of hematopoietic cancer cells.

Authors: Robert Brooks; Gwenny M Fuhler; Sonia Iyer; Michelle J Smith; Mi-Young Park; Kim H T Paraiso; Robert W Engelman; William G Kerr
Journal: J Immunol Date: 2010-03-03 Impact factor: 5.422

6. Phosphatidylinositol (3,4,5)P3 is essential but not sufficient for protein kinase B (PKB) activation; phosphatidylinositol (3,4)P2 is required for PKB phosphorylation at Ser-473: studies using cells from SH2-containing inositol-5-phosphatase knockout mice.

Authors: Michael P Scheid; Michael Huber; Jacqueline E Damen; Michael Hughes; Veronica Kang; Paul Neilsen; Glenn D Prestwich; Gerald Krystal; Vincent Duronio
Journal: J Biol Chem Date: 2002-01-07 Impact factor: 5.157

7. SHIP is required for a functional hematopoietic stem cell niche.

Authors: Amy L Hazen; Michelle J Smith; Caroline Desponts; Oliver Winter; Katrin Moser; William G Kerr
Journal: Blood Date: 2008-12-12 Impact factor: 22.113

8. Inositol 1,3,4,5-tetrakisphosphate controls proapoptotic Bim gene expression and survival in B cells.

Authors: Yoann Maréchal; Xavier Pesesse; Yonghui Jia; Valérie Pouillon; David Pérez-Morga; Julien Daniel; Shozo Izui; Peter J Cullen; Oberdan Leo; Hongbo R Luo; Christophe Erneux; Stéphane Schurmans
Journal: Proc Natl Acad Sci U S A Date: 2007-08-20 Impact factor: 11.205

9. Targeting of the GTPase Irgm1 to the phagosomal membrane via PtdIns(3,4)P(2) and PtdIns(3,4,5)P(3) promotes immunity to mycobacteria.

Authors: Sangeeta Tiwari; Han-Pil Choi; Takeshi Matsuzawa; Marc Pypaert; John D MacMicking
Journal: Nat Immunol Date: 2009-08 Impact factor: 25.606

10. The inositol polyphosphate 5-phosphatase ship is a crucial negative regulator of B cell antigen receptor signaling.

Authors: Q Liu; A J Oliveira-Dos-Santos; S Mariathasan; D Bouchard; J Jones; R Sarao; I Kozieradzki; P S Ohashi; J M Penninger; D J Dumont
Journal: J Exp Med Date: 1998-10-05 Impact factor: 14.307

53 in total

1. RNA-seq implicates deregulation of the immune system in the pathogenesis of diverticulitis.

Authors: Kathleen M Schieffer; Christine S Choi; Scott Emrich; Leonard Harris; Sue Deiling; Dipti M Karamchandani; Anna Salzberg; Yuka I Kawasawa; Gregory S Yochum; Walter A Koltun
Journal: Am J Physiol Gastrointest Liver Physiol Date: 2017-06-15 Impact factor: 4.052

Inhibitor and activator: dual functions for SHIP in immunity and cancer.

1. The terminology issue for myeloid-derived suppressor cells.

2. Inappropriate recruitment and activity by the Src homology region 2 domain-containing phosphatase 1 (SHP1) is responsible for receptor dominance in the SHIP-deficient NK cell.

3. TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1.

4. The human SHIP gene is differentially expressed in cell lineages of the bone marrow and blood.

5. SHIP1 inhibition increases immunoregulatory capacity and triggers apoptosis of hematopoietic cancer cells.

6. Phosphatidylinositol (3,4,5)P3 is essential but not sufficient for protein kinase B (PKB) activation; phosphatidylinositol (3,4)P2 is required for PKB phosphorylation at Ser-473: studies using cells from SH2-containing inositol-5-phosphatase knockout mice.

7. SHIP is required for a functional hematopoietic stem cell niche.

8. Inositol 1,3,4,5-tetrakisphosphate controls proapoptotic Bim gene expression and survival in B cells.

9. Targeting of the GTPase Irgm1 to the phagosomal membrane via PtdIns(3,4)P(2) and PtdIns(3,4,5)P(3) promotes immunity to mycobacteria.

10. The inositol polyphosphate 5-phosphatase ship is a crucial negative regulator of B cell antigen receptor signaling.

1. RNA-seq implicates deregulation of the immune system in the pathogenesis of diverticulitis.

Review 2. microRNAs function in CD8+T cell biology.

3. Role of miR-155 in the pathogenesis of herpetic stromal keratitis.

4. Human Cytomegalovirus Glycoprotein-Initiated Signaling Mediates the Aberrant Activation of Akt.

Review 5. Fig4 deficiency: a newly emerged lysosomal storage disorder?

Review 6. Inositol 5-phosphatases: insights from the Lowe syndrome protein OCRL.

Review 7. Neutrophil migration: moving from zebrafish models to human autoimmunity.

Review 8. The Next Generation of Immunotherapy for Cancer: Small Molecules Could Make Big Waves.

9. Targeting PYK2 mediates microenvironment-specific cell death in multiple myeloma.

10. Epistasis between microRNAs 155 and 146a during T cell-mediated antitumor immunity.