Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Is the role of the small intestine in first-pass metabolism overemphasized?

Literature DB >> 10353984

Is the role of the small intestine in first-pass metabolism overemphasized?

J H Lin¹, M Chiba, T A Baillie.

Abstract

Mesh：

Substances：

Year: 1999 PMID： 10353984

Source DB: PubMed Journal: Pharmacol Rev ISSN： 0031-6997 Impact factor: 25.468

Keyword Cloud
Cited

× No keyword cloud information.

47 in total

Review 1. The mucosa of the small intestine: how clinically relevant as an organ of drug metabolism?

Authors: Margaret M Doherty; William N Charman
Journal: Clin Pharmacokinet Date: 2002 Impact factor: 6.447

2. Organ data from the developing Göttingen minipig: first steps towards a juvenile PBPK model.

Authors: Els Van Peer; Noel Downes; Christophe Casteleyn; Chris Van Ginneken; Arie Weeren; Steven Van Cruchten
Journal: J Pharmacokinet Pharmacodyn Date: 2015-12-19 Impact factor: 2.745

3. Metabolomics analysis revealed metabolic changes in patients with diarrhea-predominant irritable bowel syndrome and metabolic responses to a synbiotic yogurt intervention.

Authors: Hamid Noorbakhsh; Masoud Yavarmanesh; Seyed Ali Mortazavi; Peyman Adibi; Ali A Moazzami
Journal: Eur J Nutr Date: 2018-11-03 Impact factor: 5.614

Review 4. The influence of cardiovascular physiology on dose/pharmacokinetic and pharmacokinetic/pharmacodynamic relationships.

Authors: Pietro Fagiolino; Rosa Eiraldi; Marta Vázquez
Journal: Clin Pharmacokinet Date: 2006 Impact factor: 6.447

Is the role of the small intestine in first-pass metabolism overemphasized?

Review 1. The mucosa of the small intestine: how clinically relevant as an organ of drug metabolism?

2. Organ data from the developing Göttingen minipig: first steps towards a juvenile PBPK model.

3. Metabolomics analysis revealed metabolic changes in patients with diarrhea-predominant irritable bowel syndrome and metabolic responses to a synbiotic yogurt intervention.

Review 4. The influence of cardiovascular physiology on dose/pharmacokinetic and pharmacokinetic/pharmacodynamic relationships.

Review 5. Why is it challenging to predict intestinal drug absorption and oral bioavailability in human using rat model.

6. Metabolic and efflux properties of Caco-2 cells stably transfected with nuclear receptors.

Review 7. The conduct of drug metabolism studies considered good practice (I): analytical systems and in vivo studies.

Review 8. Prediction of hepatic clearance in human from in vitro data for successful drug development.

9. Loss of orally administered drugs in GI tract.

10. Relative importance of intestinal and hepatic glucuronidation-impact on the prediction of drug clearance.