Literature DB >> 10348789

In vitro activities of pyronaridine, alone and in combination with other antimalarial drugs, against Plasmodium falciparum.

P Ringwald1, E C Eboumbou, J Bickii, L K Basco.   

Abstract

The in vitro activities of pyronaridine, alone and in combination with established antimalarial drugs, were assessed by isotopic microtest. Pyronaridine was highly active against all Cameroonian isolates. A positive correlation was observed between the response to pyronaridine and that to chloroquine. Drug combination studies showed synergy between pyronaridine and primaquine, additive effects with 4-aminoquinolines, and weak antagonism with dihydroartemisinin, antifolates, or amino alcohols.

Entities:  

Mesh：

Substances：

Year:  1999        PMID： 10348789      PMCID： PMC89315          DOI： 10.1128/AAC.43.6.1525

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  19 in total

1.  The chemotherapy of rodent malaria. XLVII. Studies on pyronaridine and other Mannich base antimalarials.

Authors:  W Peters; B L Robinson
Journal:  Ann Trop Med Parasitol       Date:  1992-10

2.  Strategies for the prevention of antimalarial drug resistance: rationale for combination chemotherapy for malaria.

Authors:  N J White; P L Olliaro
Journal:  Parasitol Today       Date:  1996-10

3.  Positive relationship between the response of Plasmodium falciparum to chloroquine and pyronaridine.

Authors:  M Warsame; W H Wernsdorfer; D Payne; A Björkman
Journal:  Trans R Soc Trop Med Hyg       Date:  1991 Sep-Oct       Impact factor: 2.184

4.  In vitro activity of antimalarials against clinical isolates of Plasmodium falciparum in Yaounde, Cameroon.

Authors:  P Ringwald; J Bickii; L K Basco
Journal:  Am J Trop Med Hyg       Date:  1996-09       Impact factor: 2.345

5.  Efficacy of oral pyronaridine for the treatment of acute uncomplicated falciparum malaria in African children.

Authors:  P Ringwald; J Bickii; L K Basco
Journal:  Clin Infect Dis       Date:  1998-04       Impact factor: 9.079

6.  Activity of pyronaridine and mepacrine against twelve strains of Plasmodium falciparum in vitro.

Authors:  E I Elueze; S L Croft; D C Warhurst
Journal:  J Antimicrob Chemother       Date:  1996-03       Impact factor: 5.790

7.  The chemotherapy of rodent malaria. LV. Interactions between pyronaridine and artemisinin.

Authors:  W Peters; B L Robinson
Journal:  Ann Trop Med Parasitol       Date:  1997-03

8.  Interactions of atovaquone with other antimalarial drugs against Plasmodium falciparum in vitro.

Authors:  C J Canfield; M Pudney; W E Gutteridge
Journal:  Exp Parasitol       Date:  1995-05       Impact factor: 2.011

9.  A method for testing for synergy with any number of agents.

Authors:  M C Berenbaum
Journal:  J Infect Dis       Date:  1978-02       Impact factor: 5.226

10.  In vitro activity of pyronaridine against field isolates and reference clones of Plasmodium falciparum.

Authors:  G E Childs; B Häusler; W Milhous; C Chen; T Wimonwattrawatee; N Pooyindee; E F Boudreau
Journal:  Am J Trop Med Hyg       Date:  1988-01       Impact factor: 2.345
View more
  16 in total

1.  Baseline in vitro activities of the antimalarials pyronaridine and methylene blue against Plasmodium falciparum isolates from Kenya.

Authors:  John Okombo; Steven M Kiara; Leah Mwai; Lewa Pole; Eric Ohuma; Lynette Isabella Ochola; Alexis Nzila
Journal:  Antimicrob Agents Chemother       Date:  2011-11-28       Impact factor: 5.191

2.  Targeting of hematin by the antimalarial pyronaridine.

Authors:  Saranya Auparakkitanon; Soebsakul Chapoomram; Kannika Kuaha; Thamrong Chirachariyavej; Prapon Wilairat
Journal:  Antimicrob Agents Chemother       Date:  2006-06       Impact factor: 5.191

3.  In vitro activity of pyronaridine against multidrug-resistant Plasmodium falciparum and Plasmodium vivax.

Authors:  R N Price; J Marfurt; F Chalfein; E Kenangalem; K A Piera; E Tjitra; N M Anstey; B Russell
Journal:  Antimicrob Agents Chemother       Date:  2010-09-27       Impact factor: 5.191

4.  Population pharmacokinetics of artesunate and dihydroartemisinin following single- and multiple-dosing of oral artesunate in healthy subjects.

Authors:  Beesan Tan; Himanshu Naik; In-Jin Jang; Kyung-Sang Yu; Lee E Kirsch; Chang-Sik Shin; J Carl Craft; Lawrence Fleckenstein
Journal:  Malar J       Date:  2009-12-18       Impact factor: 2.979

Review 5.  Artesunate plus pyronaridine for treating uncomplicated Plasmodium falciparum malaria.

Authors:  Hasifa Bukirwa; B Unnikrishnan; Christine V Kramer; David Sinclair; Suma Nair; Prathap Tharyan
Journal:  Cochrane Database Syst Rev       Date:  2014-03-04

6.  Synergism between pyronaridine and retinol in Plasmodium falciparum in vitro.

Authors:  Pippa Proell; Kanungnit Congpuong; Franz F Reinthaler; Gunther Wernsdorfer; Ursula Wiedermann; Walther H Wernsdorfer
Journal:  Wien Klin Wochenschr       Date:  2009-10       Impact factor: 1.704

7.  Review of pyronaridine anti-malarial properties and product characteristics.

Authors:  Simon L Croft; Stephan Duparc; Sarah J Arbe-Barnes; J Carl Craft; Chang-Sik Shin; Lawrence Fleckenstein; Isabelle Borghini-Fuhrer; Han-Jong Rim
Journal:  Malar J       Date:  2012-08-09       Impact factor: 2.979

8.  Absence of association between pyronaridine in vitro responses and polymorphisms in genes involved in quinoline resistance in Plasmodium falciparum.

Authors:  Bruno Pradines; Sébastien Briolant; Maud Henry; Claude Oeuvray; Eric Baret; Rémy Amalvict; Eric Didillon; Christophe Rogier
Journal:  Malar J       Date:  2010-11-25       Impact factor: 2.979

9.  Failure of Supervised Chloroquine and Primaquine Regimen for the Treatment of Plasmodium vivax in the Peruvian Amazon.

Authors:  Paul C F Graf; Salomon Durand; Carlos Alvarez Antonio; Carmen Montalvan; Mariella Galves Montoya; Michael D Green; Meddly L Santolalla; Carola Salas; Carmen Lucas; David J Bacon; David J Fryauff
Journal:  Malar Res Treat       Date:  2012-05-31

10.  Ex vivo activity of the ACT new components pyronaridine and piperaquine in comparison with conventional ACT drugs against isolates of Plasmodium falciparum.

Authors:  Aurélie Pascual; Philippe Parola; Françoise Benoit-Vical; Fabrice Simon; Denis Malvy; Stéphane Picot; Pascal Delaunay; Didier Basset; Danièle Maubon; Bernard Faugère; Guillaume Ménard; Nathalie Bourgeois; Claude Oeuvray; Eric Didillon; Christophe Rogier; Bruno Pradines
Journal:  Malar J       Date:  2012-02-14       Impact factor: 2.979
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.