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Literature DB >> 10348781

Interstrain variation in the human cytomegalovirus DNA polymerase sequence and its effect on genotypic diagnosis of antiviral drug resistance. Adult AIDS Clinical Trials Group CMV Laboratories.

S Chou¹, N S Lurain, A Weinberg, G Y Cai, P L Sharma, C S Crumpacker.

Abstract

The polymerase (pol) coding sequence was determined for 40 independent clinical cytomegalovirus isolates sensitive to ganciclovir and foscarnet. Sequence alignments showed >98% interstrain homology and amino acid variation in only 4% of the 1, 237 codons. Almost all variation occurred outside of conserved functional domains where resistance mutations have been identified.

Entities: Chemical Disease Species

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Year: 1999 PMID： 10348781 PMCID： PMC89307 DOI： 10.1128/AAC.43.6.1500

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

14 in total

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27 in total

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Authors: Anne-Marie Fillet; Laetitia Auray; Sophie Alain; Karine Gourlain; Berthe Marie Imbert; Fatiha Najioullah; Gael Champier; Stéphanie Gouarin; Jocelyne Carquin; Nadhira Houhou; Isabelle Garrigue; Alexandra Ducancelle; Danielle Thouvenot; Marie-Christine Mazeron
Journal: Antimicrob Agents Chemother Date: 2004-05 Impact factor: 5.191

2. Cytomegalovirus retinitis and the acquired immunodeficiency syndrome--bench to bedside: LXVII Edward Jackson Memorial Lecture.

Authors: Douglas A Jabs
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Authors: C Gilbert; G Boivin
Journal: Antimicrob Agents Chemother Date: 2005-03 Impact factor: 5.191

4. Differentiation between polymorphisms and resistance-associated mutations in human cytomegalovirus DNA polymerase.

Authors: Meike Chevillotte; Ina Ersing; Thomas Mertens; Jens von Einem
Journal: Antimicrob Agents Chemother Date: 2010-09-27 Impact factor: 5.191

5. Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial.

Authors: Sunwen Chou; Guy Boivin; Jane Ives; Robert Elston
Journal: J Infect Dis Date: 2013-11-23 Impact factor: 5.226

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Authors: C Gilbert; G Boivin
Journal: Antimicrob Agents Chemother Date: 2005-12 Impact factor: 5.191

7. Recombinant phenotyping of cytomegalovirus UL54 mutations that emerged during cell passages in the presence of either ganciclovir or foscarnet.

Authors: Christian Gilbert; Arezki Azzi; Nathalie Goyette; Sheng-Xiang Lin; Guy Boivin
Journal: Antimicrob Agents Chemother Date: 2011-06-27 Impact factor: 5.191