Literature DB >> 15105145

Natural polymorphism of cytomegalovirus DNA polymerase lies in two nonconserved regions located between domains delta-C and II and between domains III and I.

Anne-Marie Fillet1, Laetitia Auray, Sophie Alain, Karine Gourlain, Berthe Marie Imbert, Fatiha Najioullah, Gael Champier, Stéphanie Gouarin, Jocelyne Carquin, Nadhira Houhou, Isabelle Garrigue, Alexandra Ducancelle, Danielle Thouvenot, Marie-Christine Mazeron.   

Abstract

We described the natural polymorphism of cytomegalovirus DNA polymerase in 42 unrelated isolates susceptible to ganciclovir, foscarnet, and cidofovir. All variations, including an eight-amino-acid deletion, were located between domains delta-C and II and between domains III and I, suggesting that these specific residues are not involved in enzymatic functions.

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Year:  2004        PMID： 15105145      PMCID： PMC400574          DOI： 10.1128/AAC.48.5.1865-1868.2004

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  35 in total

1.  Viral DNA polymerase mutations associated with drug resistance in human cytomegalovirus.

Authors:  Sunwen Chou; Nell S Lurain; Kenneth D Thompson; Richard C Miner; W Lawrence Drew
Journal:  J Infect Dis       Date:  2003-06-16       Impact factor: 5.226

2.  Failure of ganciclovir treatment associated with selection of a ganciclovir-resistant cytomegalovirus strain in a lung transplant recipient.

Authors:  S Alain; P Honderlick; D Grenet; M Stern; C Vadam; M J Sanson-Le Pors; M C Mazeron
Journal:  Transplantation       Date:  1997-05-27       Impact factor: 4.939

3.  Compilation, alignment, and phylogenetic relationships of DNA polymerases.

Authors:  D K Braithwaite; J Ito
Journal:  Nucleic Acids Res       Date:  1993-02-25       Impact factor: 16.971

4.  Antiviral susceptibilities and analysis of UL97 and DNA polymerase sequences of clinical cytomegalovirus isolates from immunocompromised patients.

Authors:  A Erice; C Gil-Roda; J L Pérez; H H Balfour; K J Sannerud; M N Hanson; G Boivin; S Chou
Journal:  J Infect Dis       Date:  1997-05       Impact factor: 5.226

5.  Mutations conferring foscarnet resistance in a cohort of patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis.

Authors:  Adriana Weinberg; Douglas A Jabs; Sunwen Chou; Barbara K Martin; Nell S Lurain; Michael S Forman; Clyde Crumpacker
Journal:  J Infect Dis       Date:  2003-02-24       Impact factor: 5.226

6.  Point mutations in the DNA polymerase gene of human cytomegalovirus that result in resistance to antiviral agents.

Authors:  N S Lurain; K D Thompson; E W Holmes; G S Read
Journal:  J Virol       Date:  1992-12       Impact factor: 5.103

Review 7.  Human cytomegalovirus resistance to antiviral drugs: diagnosis, monitoring and clinical impact.

Authors:  Fausto Baldanti; Giuseppe Gerna
Journal:  J Antimicrob Chemother       Date:  2003-07-29       Impact factor: 5.790

8.  Comparison of sequential cytomegalovirus isolates in a patient with lymphoma and failing antiviral therapy.

Authors:  Alexandra Ducancelle; Stéphanie Belloc; Sophie Alain; Catherine Scieux; Marion Malphettes; Françoise Petit; Jean-Claude Brouet; Marie-José Sanson Le Pors; Marie-Christine Mazeron
Journal:  J Clin Virol       Date:  2004-04       Impact factor: 3.168

9.  Emergence of late cytomegalovirus central nervous system disease in hematopoietic stem cell transplant recipients.

Authors:  Dana G Wolf; Nell S Lurain; Tsila Zuckerman; Ron Hoffman; Judith Satinger; Alik Honigman; Niveen Saleh; Emanuel S Robert; Jacob M Rowe; Zipora Kra-Oz
Journal:  Blood       Date:  2002-08-22       Impact factor: 22.113

10.  A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells.

Authors:  V Sullivan; C L Talarico; S C Stanat; M Davis; D M Coen; K K Biron
Journal:  Nature       Date:  1992-07-09       Impact factor: 49.962
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  6 in total

1.  Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial.

Authors:  Sunwen Chou; Guy Boivin; Jane Ives; Robert Elston
Journal:  J Infect Dis       Date:  2013-11-23       Impact factor: 5.226

2.  New reporter cell line to evaluate the sequential emergence of multiple human cytomegalovirus mutations during in vitro drug exposure.

Authors:  C Gilbert; G Boivin
Journal:  Antimicrob Agents Chemother       Date:  2005-12       Impact factor: 5.191

Review 3.  Antiviral drug resistance of human cytomegalovirus.

Authors:  Nell S Lurain; Sunwen Chou
Journal:  Clin Microbiol Rev       Date:  2010-10       Impact factor: 26.132

4.  Novel method based on "en passant" mutagenesis coupled with a gaussia luciferase reporter assay for studying the combined effects of human cytomegalovirus mutations.

Authors:  Emilien Drouot; Jocelyne Piret; Guy Boivin
Journal:  J Clin Microbiol       Date:  2013-07-17       Impact factor: 5.948

5.  Functional characterization of novel mutations in UL54 of ganciclovir resistant HCMV strain using structural analysis.

Authors:  Jambulingam Malathi; Vetrivel Umashankar; Ravichandran Sathyabaarathi; Sivashanmugan Muthukumaran; Murali Ishwarya; Hajib Narahari Madhavan
Journal:  Bioinformation       Date:  2011-02-07

6.  Cytomegalovirus Infection and the Implications of Drug-Resistant Mutations in Pediatric Allogeneic Hematopoietic Stem Cell Transplant Recipients: A Retrospective Study from a Tertiary Hospital in China.

Authors:  Uet Yu; Xiaodong Wang; Xiaoling Zhang; Chunjing Wang; Chunlan Yang; Xiaohui Zhou; Yue Li; Xiaochan Huang; Jing Wen; Feiqiu Wen; Sixi Liu
Journal:  Infect Dis Ther       Date:  2021-05-08
  6 in total

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