| Literature DB >> 10346865 |
D L Ladd1, R Hollister, X Peng, D Wei, G Wu, D Delecki, R A Snow, J L Toner, K Kellar, J Eck, V C Desai, G Raymond, L B Kinter, T S Desser, D L Rubin.
Abstract
We have synthesized and evaluated five series of polymeric gadolinium chelates which are of interest as potential MRI blood pool contrast agents. The polymers were designed so that important physical properties including molecular weight, relaxivity, metal content, viscosity, and chelate stability could be varied. We have shown that, by selecting polymers of the appropriate MW, extended blood pool retention can be achieved. In addition, relaxivity can be manipulated by changing the polymer rigidity, metal content affected by monomer selection, viscosity by polymer shape, and chelate stability by chelator selection.Entities:
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Year: 1999 PMID： 10346865 DOI： 10.1021/bc980086+
Source DB: PubMed Journal: Bioconjug Chem ISSN： 1043-1802 Impact factor: 4.774