Literature DB >> 20590365

Macromolecular and dendrimer-based magnetic resonance contrast agents.

Ambika Bumb1, Martin W Brechbiel, Peter Choyke.   

Abstract

Magnetic resonance imaging (MRI) is a powerful imaging modality that can provide an assessment of function or molecular expression in tandem with anatomic detail. Over the last 20-25 years, a number of gadolinium-based MR contrast agents have been developed to enhance signal by altering proton relaxation properties. This review explores a range of these agents from small molecule chelates, such as Gd-DTPA and Gd-DOTA, to macromolecular structures composed of albumin, polylysine, polysaccharides (dextran, inulin, starch), poly(ethylene glycol), copolymers of cystamine and cystine with GD-DTPA, and various dendritic structures based on polyamidoamine and polylysine (Gadomers). The synthesis, structure, biodistribution, and targeting of dendrimer-based MR contrast agents are also discussed.

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Year:  2010        PMID： 20590365      PMCID： PMC2922462          DOI： 10.3109/02841851.2010.491091

Source DB:  PubMed          Journal:  Acta Radiol        ISSN： 0284-1851            Impact factor:   1.990


  84 in total

1.  A multinuclear MR study of Gd-EOB-DTPA: comprehensive preclinical characterization of an organ specific MRI contrast agent.

Authors:  L Vander Elst; F Maton; S Laurent; F Seghi; F Chapelle; R N Muller
Journal:  Magn Reson Med       Date:  1997-10       Impact factor: 4.668

2.  Development of a tumor-targeting MR contrast agent using the high-affinity folate receptor: work in progress.

Authors:  S D Konda; M Aref; M Brechbiel; E C Wiener
Journal:  Invest Radiol       Date:  2000-01       Impact factor: 6.016

Review 3.  Gadolinium meets medicinal chemistry: MRI contrast agent development.

Authors:  Zhaoda Zhang; Shrikumar A Nair; Thomas J McMurry
Journal:  Curr Med Chem       Date:  2005       Impact factor: 4.530

Review 4.  PAMAM dendrimer based macromolecules as improved contrast agents.

Authors:  Vincent J Venditto; Celeste Aida S Regino; Martin W Brechbiel
Journal:  Mol Pharm       Date:  2005 Jul-Aug       Impact factor: 4.939

5.  Contrast-enhanced MRI with new biodegradable macromolecular Gd(III) complexes in tumor-bearing mice.

Authors:  Yuda Zong; Xinghe Wang; K Craig Goodrich; Aaron M Mohs; Dennis L Parker; Zheng-Rong Lu
Journal:  Magn Reson Med       Date:  2005-04       Impact factor: 4.668

6.  The relationship of glycosylation and isoelectric point with tumor accumulation of avidin.

Authors:  Z Yao; M Zhang; H Sakahara; Y Nakamoto; T Higashi; S Zhao; N Sato; Y Arano; J Konishi
Journal:  J Nucl Med       Date:  1999-03       Impact factor: 10.057

7.  A new polysaccharide macromolecular contrast agent for MR imaging: biodistribution and imaging characteristics.

Authors:  T H Helbich; A Gossman; P A Mareski; B Radüchel; T P Roberts; D M Shames; M Mühler; K Turetschek; R C Brasch
Journal:  J Magn Reson Imaging       Date:  2000-06       Impact factor: 4.813

8.  Biliary secretion of fluid-phase markers by the isolated perfused rat liver. Role of transcellular vesicular transport.

Authors:  J R Lake; V Licko; R W Van Dyke; B F Scharschmidt
Journal:  J Clin Invest       Date:  1985-08       Impact factor: 14.808

9.  Biodistribution of anti-CEA F(ab')2 fragments conjugated with chelating polymers: influence of conjugate electron charge on tumor uptake and blood clearance.

Authors:  M A Slinkin; C Curtet; A Faivre-Chauvet; C Sai-Maurel; J F Gestin; V P Torchilin; J F Chatal
Journal:  Nucl Med Biol       Date:  1993-05       Impact factor: 2.408

10.  PEG-g-poly(GdDTPA-co-L-cystine): a biodegradable macromolecular blood pool contrast agent for MR imaging.

Authors:  Aaron M Mohs; Xinghe Wang; K Craig Goodrich; Yuda Zong; Dennis L Parker; Zheng-Rong Lu
Journal:  Bioconjug Chem       Date:  2004 Nov-Dec       Impact factor: 4.774
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  18 in total

1.  Evaluation of a novel macromolecular cascade-polymer contrast medium for dynamic contrast-enhanced MRI monitoring of antiangiogenic bevacizumab therapy in a human melanoma model.

Authors:  Clemens C Cyran; Yanjun Fu; Victor Rogut; Bundit Chaopathomkul; Michael F Wendland; David M Shames; Robert C Brasch
Journal:  Acad Radiol       Date:  2013-10       Impact factor: 3.173

2.  Binding of a dimeric manganese porphyrin to serum albumin: towards a gadolinium-free blood-pool T1 MRI contrast agent.

Authors:  Weiran Cheng; Tameshwar Ganesh; Francisco Martinez; Jolie Lam; Hyung Yoon; Robert B Macgregor; Timothy J Scholl; Hai-Ling Margaret Cheng; Xiao-an Zhang
Journal:  J Biol Inorg Chem       Date:  2014-01-10       Impact factor: 3.358

Review 3.  Gd-based macromolecules and nanoparticles as magnetic resonance contrast agents for molecular imaging.

Authors:  Ching-Hui Huang; Andrew Tsourkas
Journal:  Curr Top Med Chem       Date:  2013       Impact factor: 3.295

4.  Stearic Acid-Grafted Chitooligosaccharide Nanomicelle System with Biocleavable Gadolinium Chelates as a Multifunctional Agent for Tumor Imaging and Drug Delivery.

Authors:  Chuhua Xin; Xiuzhong Yao; Bin Du; Weiyu Yang; Liuguo Wang; Lirong Ma; Weiyu Weng
Journal:  Pharm Res       Date:  2018-11-08       Impact factor: 4.200

5.  Conjugation effects of various linkers on Gd(III) MRI contrast agents with dendrimers: optimizing the hydroxypyridinonate (HOPO) ligands with nontoxic, degradable esteramide (EA) dendrimers for high relaxivity.

Authors:  William C Floyd; Piper J Klemm; Danil E Smiles; Ayano C Kohlgruber; Valérie C Pierre; Justin L Mynar; Jean M J Fréchet; Kenneth N Raymond
Journal:  J Am Chem Soc       Date:  2011-02-04       Impact factor: 15.419

6.  The potential of theragnostic ¹²⁴I-8H9 convection-enhanced delivery in diffuse intrinsic pontine glioma.

Authors:  Neal Luther; Zhiping Zhou; Pat Zanzonico; Nai-Kong Cheung; John Humm; Mark A Edgar; Mark M Souweidane
Journal:  Neuro Oncol       Date:  2014-02-12       Impact factor: 12.300

7.  Analysis of Lanthanide Complex Dendrimer Conjugates for Bimodal NIR and MRI Imaging.

Authors:  Christopher M Andolina; Piper J Klemm; William C Floyd; Jean M J Fréchet; Kenneth N Raymond
Journal:  Macromolecules       Date:  2012-11-12       Impact factor: 5.985

8.  Manganese(III) porphyrins complexed with P22 virus-like particles as T1-enhanced contrast agents for magnetic resonance imaging.

Authors:  Shefah Qazi; Masaki Uchida; Robert Usselman; Riley Shearer; Ethan Edwards; Trevor Douglas
Journal:  J Biol Inorg Chem       Date:  2013-12-21       Impact factor: 3.358

9.  Synthesis and evaluation of a polydisulfide with Gd-DOTA monoamide side chains as a biodegradable macromolecular contrast agent for MR blood pool imaging.

Authors:  Zhen Ye; Xueming Wu; Mingqian Tan; Jack Jesberger; Mark Grisworld; Zheng-Rong Lu
Journal:  Contrast Media Mol Imaging       Date:  2013 May-Jun       Impact factor: 3.161

10.  Radiolabeling optimization and characterization of (68)Ga labeled DOTA-polyamido-amine dendrimer conjugate - Animal biodistribution and PET imaging results.

Authors:  Aanchal Ghai; Baljinder Singh; Puja Panwar Hazari; Michael K Schultz; Ambika Parmar; Pardeep Kumar; Sarika Sharma; Devinder Dhawan; Anil Kumar Mishra
Journal:  Appl Radiat Isot       Date:  2015-07-22       Impact factor: 1.513
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