Literature DB >> 10340618

Novel bisbenzamidines and bisbenzimidazolines as noncompetitive NMDA receptor antagonists.

B Tao1, T L Huang, T A Sharma, I J Reynolds, I O Donkor.   

Abstract

A series of novel bisbenzamidines and bisbenzimidazolines with different linkers connecting the aromatic groups was tested in vitro for NMDA receptor antagonist activity. IC50 values for these compounds ranged from 1.2 to >200 microM. The bisbenzamidine with a homopiperazine ring as the central linker was found to be the most potent NMDA receptor antagonist among all the pentamidine analogues tested so far.

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Year:  1999        PMID： 10340618     DOI： 10.1016/s0960-894x(99)00184-5

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  Pentamidine analogs as inhibitors of [(3)H]MK-801 and [(3)H]ifenprodil binding to rat brain NMDA receptors.

Authors:  Michael L Berger; Dorota Maciejewska; Jean Jacques Vanden Eynde; Madhusoodanan Mottamal; Jerzy Żabiński; Paweł Kaźmierczak; Mateusz Rezler; Ivana Jarak; Ivo Piantanida; Grace Karminski-Zamola; Annie Mayence; Patrick Rebernik; Arvind Kumar; Mohamed A Ismail; David W Boykin; Tien L Huang
Journal:  Bioorg Med Chem       Date:  2015-06-14       Impact factor: 3.641

2.  Design and synthesis of N¹,N⁵-bis[4-(5-alkyl-1,2,4-oxadiazol-3-yl)phenyl]glutaramides as potential antifungal prodrugs.

Authors:  Nageswara Rao Kode; Jean J Vanden Eynde; Annie Mayence; Guangdi Wang; Tien L Huang
Journal:  Molecules       Date:  2013-09-12       Impact factor: 4.411
  2 in total

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