Literature DB >> 10339666

Analysis of cyclin dependent kinase inhibitors in malignant astrocytomas.

C H Alleyne1, J He, J Yang, S B Hunter, G Cotsonis, C D James, J J Olson.   

Abstract

The cyclin-dependent kinase inhibitors p16, p21, and p27 in human brain, and brain tumors were examined to explore clinicopathologic correlations. Western analysis and immunohistochemistry was performed and correlated retrospectively with the patients clinical characteristics. A trend was found between increased progression-free survival and p27 expression. There was no correlation between p27 expression and age or gender. The expression of p27 in malignant gliomas may have prognostic value. In addition, an investigation of the therapeutic benefit of overexpression of this cyclin-dependent kinase inhibitor is warranted given reports of diminished malignant potential of tumors expressing p27.

Entities:  

Mesh：

Substances：

Year:  1999        PMID： 10339666     DOI： 10.3892/ijo.14.6.1111

Source DB:  PubMed          Journal:  Int J Oncol        ISSN： 1019-6439            Impact factor:   5.650


  9 in total

1.  Metastasis tumor-associated protein-2 knockdown suppresses the proliferation and invasion of human glioma cells in vitro and in vivo.

Authors:  Chun-Yuan Cheng; Ying-Erh Chou; Chung-Po Ko; Shun-Fa Yang; Shu-Ching Hsieh; Chia-Liang Lin; Yi-Hsien Hsieh; Kun-Chung Chen
Journal:  J Neurooncol       Date:  2014-07-22       Impact factor: 4.130

Review 2.  Genes and pathways driving glioblastomas in humans and murine disease models.

Authors:  Adrian Merlo
Journal:  Neurosurg Rev       Date:  2003-05-29       Impact factor: 3.042

3.  Immunohistochemical markers for prognosis of ependymal neoplasms.

Authors:  Andrey Korshunov; Andrey Golanov; Valery Timirgaz
Journal:  J Neurooncol       Date:  2002-07       Impact factor: 4.130

4.  Immunohistochemical markers for prognosis of anaplastic astrocytomas.

Authors:  Andrey Korshunov; Andrey Golanov; Regina Sycheva
Journal:  J Neurooncol       Date:  2002-07       Impact factor: 4.130

5.  Immunohistochemical markers for prognosis of oligodendroglial neoplasms.

Authors:  Andrey Korshunov; Andrey Golanov; Regina Sycheva
Journal:  J Neurooncol       Date:  2002-07       Impact factor: 4.130

6.  Over-expression of BMPR-IB reduces the malignancy of glioblastoma cells by upregulation of p21 and p27Kip1.

Authors:  Shuang Liu; Feng Yin; Wenhong Fan; Shuwei Wang; Xin-ru Guo; Jian-ning Zhang; Zeng-min Tian; Ming Fan
Journal:  J Exp Clin Cancer Res       Date:  2012-05-31

7.  The Cell Cycle Inhibitors p21Cip1 and p27Kip1 Control Proliferation but Enhance DNA Damage Resistance of Glioma Stem Cells.

Authors:  Olivia Morris-Hanon; Verónica Alejandra Furmento; María Soledad Rodríguez-Varela; Sofía Mucci; Damián Darío Fernandez-Espinosa; Leonardo Romorini; Gustavo Emilio Sevlever; María Elida Scassa; Guillermo Agustín Videla-Richardson
Journal:  Neoplasia       Date:  2017-06-02       Impact factor: 5.715

8.  Differential expression and role of p21cip/waf1 and p27kip1 in TNF-alpha-induced inhibition of proliferation in human glioma cells.

Authors:  Pabbisetty Sudheer Kumar; Anjali Shiras; Gowry Das; Jayashree C Jagtap; Vandna Prasad; Padma Shastry
Journal:  Mol Cancer       Date:  2007-06-12       Impact factor: 27.401

9.  Antitumour effect of cyclin-dependent kinase inhibitors (p16(INK4A), p18(INK4C), p19(INK4D), p21(WAF1/CIP1) and p27(KIP1)) on malignant glioma cells.

Authors:  T Komata; T Kanzawa; H Takeuchi; I M Germano; M Schreiber; Y Kondo; S Kondo
Journal:  Br J Cancer       Date:  2003-04-22       Impact factor: 7.640
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.