Literature DB >> 1033831

The role of biotransformation in chemical-induced liver injury.

J R Mitchell, W R Snodgrass, J R Gillette.   

Abstract

The role of drug metabolism in chemical-induced liver injury is reviewed. Parameters for studying the formation of chemically reactive metabolites are discussed and the factors that alter the formation and covalent binding of reactive metabolites are selectively emphasized. Some of the experimental work that led to these concepts is discussed, especially the chemical toxicology of the hepatic injury produced by acetaminophen, bromobenzene, furosemide, isoniazid and iproniazid.

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Year:  1976        PMID： 1033831      PMCID： PMC1475156          DOI： 10.1289/ehp.761527

Source DB:  PubMed          Journal:  Environ Health Perspect        ISSN： 0091-6765            Impact factor:   9.031


  29 in total

1.  Biochemical studies of toxic agents. 11. The occurrence of premercapturic acids.

Authors:  R H KNIGHT; L YOUNG
Journal:  Biochem J       Date:  1958-09       Impact factor: 3.857

2.  Studies in detoxication. 51. The determination of catechols in urine, and the formation of catechols in rabbits receiving halogenobenzenes and other compounds; dihydroxylation in vivo.

Authors:  W M AZOUZ; D V PARKE; R T WILLIAMS
Journal:  Biochem J       Date:  1953-08       Impact factor: 3.857

3.  Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite.

Authors:  D J Jollow; J R Mitchell; N Zampaglione; J R Gillette
Journal:  Pharmacology       Date:  1974       Impact factor: 2.547

4.  Acetaminophen-induced hepatic necrosis. 3. Cytochrome P-450-mediated covalent binding in vitro.

Authors:  W Z Potter; D C Davis; J R Mitchell; D J Jollow; J R Gillette; B B Brodie
Journal:  J Pharmacol Exp Ther       Date:  1973-10       Impact factor: 4.030

5.  Drug metabolism as a cause of drug toxicity.

Authors:  J R Mitchell; D J Jollow; J R Gillette; B B Brodie
Journal:  Drug Metab Dispos       Date:  1973 Jan-Feb       Impact factor: 3.922

6.  Acetylation rates and monthly liver function tests during one year of isoniazid preventive therapy.

Authors:  J R Mitchell; M W Long; U P Thorgeirsson; D J Jollow
Journal:  Chest       Date:  1975-08       Impact factor: 9.410

7.  Isoniazid-associated hepatitis in 114 patients.

Authors:  M Black; J R Mitchell; H J Zimmerman; K G Ishak; G R Epler
Journal:  Gastroenterology       Date:  1975-08       Impact factor: 22.682

8.  Relationship of alcohol metabolism to the potentiation of CCl 4 hepatotoxicity induced by aliphatic alcohols.

Authors:  G J Traiger; G L Plaa
Journal:  J Pharmacol Exp Ther       Date:  1972-12       Impact factor: 4.030

9.  Possible mechanism of liver necrosis caused by aromatic organic compounds.

Authors:  B B Brodie; W D Reid; A K Cho; G Sipes; G Krishna; J R Gillette
Journal:  Proc Natl Acad Sci U S A       Date:  1971-01       Impact factor: 11.205

Review 10.  Isoniazid liver injury: clinical spectrum, pathology, and probable pathogenesis.

Authors:  J R Mitchell; H J Zimmerman; K G Ishak; U P Thorgeirsson; J A Timbrell; W R Snodgrass; S D Nelson
Journal:  Ann Intern Med       Date:  1976-02       Impact factor: 25.391
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  13 in total

1.  Computational Approach to Structural Alerts: Furans, Phenols, Nitroaromatics, and Thiophenes.

Authors:  Na Le Dang; Tyler B Hughes; Grover P Miller; S Joshua Swamidass
Journal:  Chem Res Toxicol       Date:  2017-03-14       Impact factor: 3.739

2.  Inbred mice strain shows neurobehavioral changes when exposed to tannery effluent.

Authors:  Joyce Moreira de Souza; Wellington Alves Mizael da Silva; Bruna de Oliveira Mendes; Abraão Tiago Batista Guimarães; Aline Sueli de Lima Rodrigues; Mateus Flores Montalvão; Dieferson da Costa Estrela; Anderson Rodrigo da Silva; Guilherme Malafaia
Journal:  Environ Sci Pollut Res Int       Date:  2016-11-02       Impact factor: 4.223

Review 3.  Idiosyncratic Drug Reactions: A 35-Year Chemical Research in Toxicology Perspective.

Authors:  Jack Uetrecht
Journal:  Chem Res Toxicol       Date:  2022-06-10       Impact factor: 3.973

4.  Effect of acute and chronic ethanol ingestion on the content of reduced glutathione of various tissues of the rat.

Authors:  V Fernández; L A Videla
Journal:  Experientia       Date:  1981-04-15

5.  Scanning electron microscopic examination of acetaminophen-induced hepatotoxicity and congestion in mice.

Authors:  R M Walker; W J Racz; T F McElligott
Journal:  Am J Pathol       Date:  1983-12       Impact factor: 4.307

6.  S-adenosyl-l-methionine protection of acetaminophen mediated oxidative stress and identification of hepatic 4-hydroxynonenal protein adducts by mass spectrometry.

Authors:  James Mike Brown; Christopher Kuhlman; Marcus V Terneus; Matthew T Labenski; Andre Benja Lamyaithong; John G Ball; Serrine S Lau; Monica A Valentovic
Journal:  Toxicol Appl Pharmacol       Date:  2014-09-22       Impact factor: 4.219

7.  Alterations in xenobiotic metabolism in the long-lived Little mice.

Authors:  Daniel Amador-Noguez; Adam Dean; Wendong Huang; Kenneth Setchell; David Moore; Gretchen Darlington
Journal:  Aging Cell       Date:  2007-05-23       Impact factor: 9.304

8.  Overview of an interlaboratory collaboration on evaluating the effects of model hepatotoxicants on hepatic gene expression.

Authors:  Roger G Ulrich; John C Rockett; G Gordon Gibson; Syril D Pettit
Journal:  Environ Health Perspect       Date:  2004-03       Impact factor: 9.031

9.  Effects of PBBs on cattle. III. Target organ modification as shown by renal function and liver biochemistry.

Authors:  F L Schanbacher; L B Willett; P D Moorhead; H D Mercer
Journal:  Environ Health Perspect       Date:  1978-04       Impact factor: 9.031

10.  Characterization of acute 4,4'-methylene dianiline hepatotoxicity in the rat.

Authors:  M B Bailie; T P Mullaney; R A Roth
Journal:  Environ Health Perspect       Date:  1993-06       Impact factor: 9.031
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