S Matsunaga1, M Yamaguchi, K Hayashi, T Sakou. 1. Department of Orthopaedic Surgery, Faculty of Medicine, Kagoshima University, Japan. shunji@med1.kufm.kagoshima-u.ac.jp
Abstract
STUDY DESIGN: The human leukocyte antigen (HLA) haplotypes in families of patients with known ossification of the posterior longitudinal ligament (OPLL) were reviewed. OBJECTIVE: To clarify how genetic factors relate to the development of OPLL. SUMMARY OF BACKGROUND DATA: The association between genetic factors and the development of OPLL is still unknown. MATERIALS AND METHODS: The association between HLA haplotypes and OPLL was studied in families of 24 patients with OPLL. RESULTS: The prevalence of OPLL was higher in the siblings showing a higher share of identical HLA haplotypes: 10 (53%) of 19 with concurrence of two strands, and 5 (24%) of 21 with concurrence of one strand. Of 21 subjects who had no HLA haplotype identical with that in OPLL patients, only one showed evidence of OPLL. CONCLUSION: Genetic factors predispose toward the development of OPLL.
STUDY DESIGN: The human leukocyte antigen (HLA) haplotypes in families of patients with known ossification of the posterior longitudinal ligament (OPLL) were reviewed. OBJECTIVE: To clarify how genetic factors relate to the development of OPLL. SUMMARY OF BACKGROUND DATA: The association between genetic factors and the development of OPLL is still unknown. MATERIALS AND METHODS: The association between HLA haplotypes and OPLL was studied in families of 24 patients with OPLL. RESULTS: The prevalence of OPLL was higher in the siblings showing a higher share of identical HLA haplotypes: 10 (53%) of 19 with concurrence of two strands, and 5 (24%) of 21 with concurrence of one strand. Of 21 subjects who had no HLA haplotype identical with that in OPLLpatients, only one showed evidence of OPLL. CONCLUSION: Genetic factors predispose toward the development of OPLL.
Authors: N Yoshimura; K Nagata; S Muraki; H Oka; M Yoshida; Y Enyo; R Kagotani; H Hashizume; H Yamada; Y Ishimoto; M Teraguchi; S Tanaka; H Kawaguchi; Y Toyama; K Nakamura; T Akune Journal: Osteoporos Int Date: 2013-08-22 Impact factor: 4.507
Authors: Dong Hwan Kim; Dong Hwan Yun; Hee-Sang Kim; Seong Ki Min; Seung Don Yoo; Kyu Hoon Lee; Ki-Tack Kim; Dae Jean Jo; Su Kang Kim; Joo-Ho Chung; Ju Yeon Ban; Sung Yong Lee Journal: Ann Rehabil Med Date: 2014-02-25