Literature DB >> 25504229

Genomic study of ossification of the posterior longitudinal ligament of the spine.

Shiro Ikegawa1.   

Abstract

Ossification of the posterior longitudinal ligament of the spine (OPLL) is a common disease after the middle age. OPLL frequently causes serious neurological problems due to compression of the spinal cord and/or nerve roots. OPLL occurs in patients with monogenic metabolic diseases including rickets/osteomalacia and hypoparathyroidism; however most of OPLL is idiopathic and is considered as a multi-factorial (polygenic) disease influenced by genetic and environmental factors. Genomic studies for the genetic factors of OPLL have been conducted, mainly in Japan, including linkage and association studies. This paper reviews the recent progress in the genomic study of OPLL and comments on its future direction.

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Year:  2014        PMID： 25504229      PMCID： PMC4335137          DOI： 10.2183/pjab.90.405

Source DB:  PubMed          Journal:  Proc Jpn Acad Ser B Phys Biol Sci        ISSN： 0386-2208            Impact factor:   3.493


  33 in total

Review 1.  Recent progress in the study of pathogenesis of ossification of the posterior longitudinal ligament.

Authors:  T Sakou; S Matsunaga; H Koga
Journal:  J Orthop Sci       Date:  2000       Impact factor: 1.601

2.  Genomewide linkage and linkage disequilibrium analyses identify COL6A1, on chromosome 21, as the locus for ossification of the posterior longitudinal ligament of the spine.

Authors:  Toshihiro Tanaka; Katsunori Ikari; Kozo Furushima; Akihiro Okada; Hiroshi Tanaka; Ken-Ichi Furukawa; Kenichi Yoshida; Toshiyuki Ikeda; Shiro Ikegawa; Steven C Hunt; Jun Takeda; Satoshi Toh; Seiko Harata; Toshiaki Nakajima; Ituro Inoue
Journal:  Am J Hum Genet       Date:  2003-09-04       Impact factor: 11.025

3.  A genome-wide sib-pair linkage analysis of ossification of the posterior longitudinal ligament of the spine.

Authors:  Tatsuki Karasugi; Masahiro Nakajima; Katsunori Ikari; Takashi Tsuji; Morio Matsumoto; Kazuhiro Chiba; Kenzo Uchida; Yoshiharu Kawaguchi; Hiroshi Mizuta; Naoshi Ogata; Motoki Iwasaki; Shingo Maeda; Takuya Numasawa; Kuniyoshi Abumi; Tsuyoshi Kato; Hiroshi Ozawa; Toshihiko Taguchi; Takashi Kaito; Masashi Neo; Masashi Yamazaki; Nobuaki Tadokoro; Munehito Yoshida; Shinnosuke Nakahara; Kenji Endo; Shiro Imagama; Satoru Demura; Kimiaki Sato; Atsushi Seichi; Shoichi Ichimura; Masahiko Watanabe; Kei Watanabe; Yutaka Nakamura; Kanji Mori; Hisatoshi Baba; Yoshiaki Toyama; Shiro Ikegawa
Journal:  J Bone Miner Metab       Date:  2012-11-09       Impact factor: 2.626

4.  Association between interleukin 15 receptor, alpha (IL15RA) polymorphism and Korean patients with ossification of the posterior longitudinal ligament.

Authors:  Dong Hwan Kim; Yong Seol Jeong; Jinmann Chon; Seung Don Yoo; Hee-Sang Kim; Sung Wook Kang; Joo-Ho Chung; Ki-Tack Kim; Dong Hwan Yun
Journal:  Cytokine       Date:  2011-09       Impact factor: 3.861

5.  Association between a polymorphism of the transforming growth factor-beta1 gene and genetic susceptibility to ossification of the posterior longitudinal ligament in Japanese patients.

Authors:  M Kamiya; A Harada; M Mizuno; H Iwata; Y Yamada
Journal:  Spine (Phila Pa 1976)       Date:  2001-06-01       Impact factor: 3.468

6.  Nucleotide pyrophosphatase gene polymorphism associated with ossification of the posterior longitudinal ligament of the spine.

Authors:  Yu Koshizuka; Hiroshi Kawaguchi; Naoshi Ogata; Toshiyuki Ikeda; Akihiko Mabuchi; Atsushi Seichi; Yusuke Nakamura; Kozo Nakamura; Shiro Ikegawa
Journal:  J Bone Miner Res       Date:  2002-01       Impact factor: 6.741

7.  Large-scale screening for candidate genes of ossification of the posterior longitudinal ligament of the spine.

Authors:  Kozo Furushima; Kazuki Shimo-Onoda; Shingo Maeda; Takahiro Nobukuni; Katsunori Ikari; Hiroaki Koga; Setsuro Komiya; Toshiaki Nakajima; Seiko Harata; Ituro Inoue
Journal:  J Bone Miner Res       Date:  2002-01       Impact factor: 6.741

8.  Mutations in ENPP1 are associated with 'idiopathic' infantile arterial calcification.

Authors:  Frank Rutsch; Nico Ruf; Sucheta Vaingankar; Mohammad R Toliat; Anita Suk; Wolfgang Höhne; Galen Schauer; Mandy Lehmann; Tony Roscioli; Dirk Schnabel; Jörg T Epplen; Alex Knisely; Andrea Superti-Furga; James McGill; Marco Filippone; Alan R Sinaiko; Hillary Vallance; Bernd Hinrichs; Wendy Smith; Merry Ferre; Robert Terkeltaub; Peter Nürnberg
Journal:  Nat Genet       Date:  2003-08       Impact factor: 38.330

9.  Association of bone metabolism regulatory factor gene polymorphisms with susceptibility to ossification of the posterior longitudinal ligament of the spine and its severity.

Authors:  Naoshi Ogata; Yu Koshizuka; Toshiki Miura; Motoshige Iwasaki; Takayuki Hosoi; Masataka Shiraki; Atsushi Seichi; Kozo Nakamura; Hiroshi Kawaguchi
Journal:  Spine (Phila Pa 1976)       Date:  2002-08-15       Impact factor: 3.468

10.  Association of a BMP9 haplotype with ossification of the posterior longitudinal ligament (OPLL) in a Chinese population.

Authors:  Yuan Ren; Zhi-zhong Liu; Jie Feng; Hong Wan; Jun-hua Li; Hao Wang; Xin Lin
Journal:  PLoS One       Date:  2012-07-19       Impact factor: 3.240
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  15 in total

1.  Role of Runx2 polymorphisms in risk and prognosis of ossification of posterior longitudinal ligament.

Authors:  Feng Chang; Lijun Li; Gang Gao; Shengqiang Ding; Jincai Yang; Ting Zhang; Genle Zuo
Journal:  J Clin Lab Anal       Date:  2016-10-05       Impact factor: 2.352

2.  Identification and Functional Characterization of RSPO2 as a Susceptibility Gene for Ossification of the Posterior Longitudinal Ligament of the Spine.

Authors:  Masahiro Nakajima; Ikuyo Kou; Hirofumi Ohashi; Shiro Ikegawa
Journal:  Am J Hum Genet       Date:  2016-06-30       Impact factor: 11.025

3.  Targeted next-generation sequencing reveals multiple deleterious variants in OPLL-associated genes.

Authors:  Xin Chen; Jun Guo; Tao Cai; Fengshan Zhang; Shengfa Pan; Li Zhang; Shaobo Wang; Feifei Zhou; Yinze Diao; Yanbin Zhao; Zhen Chen; Xiaoguang Liu; Zhongqiang Chen; Zhongjun Liu; Yu Sun; Jie Du
Journal:  Sci Rep       Date:  2016-06-01       Impact factor: 4.379

4.  MicroRNA-181 regulates the development of Ossification of Posterior longitudinal ligament via Epigenetic Modulation by targeting PBX1.

Authors:  Ning Liu; Zicheng Zhang; Li Li; Xiaolong Shen; Baifeng Sun; Ruizhe Wang; Huajian Zhong; Qianghui Shi; Leixin Wei; Yizhi Zhang; Yue Wang; Chen Xu; Yang Liu; Wen Yuan
Journal:  Theranostics       Date:  2020-06-12       Impact factor: 11.556

5.  Potential role of the IL17RC gene in the thoracic ossification of the posterior longitudinal ligament.

Authors:  Peng Wang; Xiaoguang Liu; Chao Kong; Xiao Liu; Ze Teng; Yunlong Ma; Lei Yong; Chen Liang; Guanping He; Shibao Lu
Journal:  Int J Mol Med       Date:  2019-03-12       Impact factor: 4.101

6.  Increase of the Serum FGF-23 in Ossification of the Posterior Longitudinal Ligament.

Authors:  Yoshiharu Kawaguchi; Isao Kitajima; Masato Nakano; Taketoshi Yasuda; Shoji Seki; Kayo Suzuki; Yasuhito Yahara; Hiroto Makino; Yasuhiro Ujihara; Tomohiro Ueno; Tomoatsu Kimura
Journal:  Global Spine J       Date:  2018-09-27

7.  Ossification of Posterior Longitudinal Ligament of Cervical Spine Among Omani Patients Referred for CT Scan at a Tertiary Care Hospital in Oman.

Authors:  Srinivasa R Sirasanagandla; Shaher Ali Al-Kaabi; Humoud Al Dhuhli; Ghaliya Al-Hinai; Mohamed Al Mushaiqri; Sanjay Jaju
Journal:  Oman Med J       Date:  2019-09

8.  Genetic polymorphisms in bone morphogenetic protein receptor type IA gene predisposes individuals to ossification of the posterior longitudinal ligament of the cervical spine via the smad signaling pathway.

Authors:  Hao Wang; Weitao Jin; Haibin Li
Journal:  BMC Musculoskelet Disord       Date:  2018-02-20       Impact factor: 2.362

9.  Association of IL17RC and COL6A1 genetic polymorphisms with susceptibility to ossification of the thoracic posterior longitudinal ligament in Chinese patients.

Authors:  Peng Wang; Xiao Liu; Bin Zhu; Yunlong Ma; Lei Yong; Ze Teng; Chen Liang; Guanping He; Xiaoguang Liu
Journal:  J Orthop Surg Res       Date:  2018-05-15       Impact factor: 2.359

Review 10.  The Pathogenesis of Ossification of the Posterior Longitudinal Ligament.

Authors:  Liang Yan; Rui Gao; Yang Liu; Baorong He; Shemin Lv; Dingjun Hao
Journal:  Aging Dis       Date:  2017-10-01       Impact factor: 6.745
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