Literature DB >> 10331844

DNA damage and repair in individual cells: applications of the comet assay in radiobiology.

P L Olive1.   

Abstract

The comet assay is a single-cell gel electrophoresis method that can measure a variety of types of DNA damage, and repair of damage, in individual cells. It is now in widespread use in genetic toxicology and oncology. This review describes the history of the development of this method and its applications in radiation biology, with particular emphasis on the use of the comet assay to measure heterogeneity in DNA damage in cells exposed to ionizing radiation.

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Year:  1999        PMID： 10331844     DOI： 10.1080/095530099140311

Source DB:  PubMed          Journal:  Int J Radiat Biol        ISSN： 0955-3002            Impact factor:   2.694


  36 in total

1.  The brain microenvironment preferentially enhances the radioresistance of CD133(+) glioblastoma stem-like cells.

Authors:  Muhammad Jamal; Barbara H Rath; Patricia S Tsang; Kevin Camphausen; Philip J Tofilon
Journal:  Neoplasia       Date:  2012-02       Impact factor: 5.715

2.  Cytotoxic and genotoxic effects induced by enrofloxacin-based antibiotic formulation Floxagen® in two experimental models of bovine cells in vitro: peripheral lymphocytes and cumulus cells.

Authors:  Juan Patricio Anchordoquy; Juan Mateo Anchordoquy; Noelia Nikoloff; Rocío Gambaro; Gisel Padula; Cecilia Furnus; Analía Seoane
Journal:  Environ Sci Pollut Res Int       Date:  2018-11-30       Impact factor: 4.223

3.  Genomic instability related to zinc deficiency and excess in an in vitro model: is the upper estimate of the physiological requirements recommended for children safe?

Authors:  Gisel Padula; María Virginia Ponzinibbio; Rocío Celeste Gambaro; Analía Isabel Seoane
Journal:  In Vitro Cell Dev Biol Anim       Date:  2017-05-26       Impact factor: 2.416

4.  Filamin-A as a marker and target for DNA damage based cancer therapy.

Authors:  Jingyin Yue; Huimei Lu; Jingmei Liu; Marianne Berwick; Zhiyuan Shen
Journal:  DNA Repair (Amst)       Date:  2011-11-02

5.  High Basal Levels of γH2AX in Human Induced Pluripotent Stem Cells Are Linked to Replication-Associated DNA Damage and Repair.

Authors:  Haritha Vallabhaneni; Patrick J Lynch; Guibin Chen; Kyeyoon Park; Yangtengyu Liu; Rachel Goehe; Barbara S Mallon; Manfred Boehm; Deborah A Hursh
Journal:  Stem Cells       Date:  2018-07-28       Impact factor: 6.277

6.  Deoxyribonucleic acid damage induced by doxorubicin in peripheral blood mononuclear cells: possible roles for the stress response and the deoxyribonucleic acid repair process.

Authors:  Silvina B Nadin; Laura M Vargas-Roig; F Darío Cuello-Carrión; Daniel R Ciocca
Journal:  Cell Stress Chaperones       Date:  2003       Impact factor: 3.667

7.  Lithium-mediated protection of hippocampal cells involves enhancement of DNA-PK-dependent repair in mice.

Authors:  Eddy S Yang; Hong Wang; Guochun Jiang; Somaira Nowsheen; Allie Fu; Dennis E Hallahan; Fen Xia
Journal:  J Clin Invest       Date:  2009-05       Impact factor: 14.808

8.  Mdm2 promotes genetic instability and transformation independent of p53.

Authors:  Alyssa Bouska; Tamara Lushnikova; Silvia Plaza; Christine M Eischen
Journal:  Mol Cell Biol       Date:  2008-06-09       Impact factor: 4.272

9.  CD133+ glioblastoma stem-like cells are radiosensitive with a defective DNA damage response compared with established cell lines.

Authors:  Amy M McCord; Muhammad Jamal; Eli S Williams; Kevin Camphausen; Philip J Tofilon
Journal:  Clin Cancer Res       Date:  2009-08-11       Impact factor: 12.531

10.  In vitro safety assessment of the strawberry tree (Arbutus unedo L.) water leaf extract and arbutin in human peripheral blood lymphocytes.

Authors:  K Jurica; I Brčić Karačonji; A Mikolić; D Milojković-Opsenica; V Benković; N Kopjar
Journal:  Cytotechnology       Date:  2018-04-25       Impact factor: 2.058
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