Literature DB >> 10328307

Synthesis and activity of sulfonamide-substituted 4,5-diaryl thiazoles as selective cyclooxygenase-2 inhibitors.

J S Carter1, S Kramer, J J Talley, T Penning, P Collins, M J Graneto, K Seibert, C M Koboldt, J Masferrer, B Zweifel.   

Abstract

A series of sulfonamide-substituted 4,5-diarylthiazoles was prepared via three synthetic routes as selective COX-2 inhibitors. Recently in the synthesis of selective COX-2 inhibitors we have discovered that the sulfonamide moiety is a suitable replacement for the methylsulfonyl moiety yielding compounds with activity both in vitro and in vivo.

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Year:  1999        PMID： 10328307     DOI： 10.1016/s0960-894x(99)00157-2

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  13 in total

1.  A Facile Approach to the Synthesis of 3,4-Disubstituted-2-Aminothiazolium Derivatives through the Use of A "Volatilizable" Support.

Authors:  Yangmei Li; Marc Giulianotti; Richard A Houghten
Journal:  Tetrahedron Lett       Date:  2010-10-27       Impact factor: 2.415

2.  Synthesis, anticancer, and anti-inflammatory activity evaluation of methanesulfonamide and amidine derivatives of 3,4-diaryl-2-imino-4-thiazolines.

Authors:  Sham M Sondhi; Reshma Rani; P P Gupta; S K Agrawal; A K Saxena
Journal:  Mol Divers       Date:  2009-03-07       Impact factor: 2.943

3.  Selective COX-2 Inhibitors: A Review of Their Structure-Activity Relationships.

Authors:  Afshin Zarghi; Sara Arfaei
Journal:  Iran J Pharm Res       Date:  2011       Impact factor: 1.696

4.  Pyrimidine containing furanose derivative having antifungal, antioxidant, and anticancer activity.

Authors:  Rupesh Dudhe; Pramod Kumar Sharma; Prabhakar Kumar Verma
Journal:  Org Med Chem Lett       Date:  2014-07-27

5.  Synthesis of New 3-Heteroarylindoles as Potential Anticancer Agents.

Authors:  Abdou O Abdelhamid; Sobhi M Gomha; Nadia A Abdelriheem; Saher M Kandeel
Journal:  Molecules       Date:  2016-07-16       Impact factor: 4.411

6.  A facile synthesis, and antimicrobial and anticancer activities of some pyridines, thioamides, thiazole, urea, quinazoline, β-naphthyl carbamate, and pyrano[2,3-d]thiazole derivatives.

Authors:  Yasser H Zaki; Marwa S Al-Gendey; Abdou O Abdelhamid
Journal:  Chem Cent J       Date:  2018-06-20       Impact factor: 4.215

7.  Myeloperoxidase content is a marker of systemic inflammation in a chronic condition: the example given by the periodontal disease in rats.

Authors:  Celso Martins Queiroz-Junior; Cinthia Mara da Fonseca Pacheco; Allyson Henrique Fonseca; André Klein; Marcelo Vidigal Caliari; Janetti Nogueira de Francischi
Journal:  Mediators Inflamm       Date:  2009-12-31       Impact factor: 4.711

8.  Crystal structure of methyl (2Z)-2-[(2Z)-2-(2-cyclo-pentyl-idenehydrazin-1-yl-idene)-4-oxo-3-phenyl-1,3-thia-zolidin-5-yl-idene]ethano-ate.

Authors:  Mehmet Akkurt; Victoria A Smolenski; Shaaban K Mohamed; Jerry P Jasinski; Alaa A Hassan; Mustafa R Albayati
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2015-09-26

9.  Synthesis, Characterization and Molecular Docking of Novel Bioactive Thiazolyl-Thiazole Derivatives as Promising Cytotoxic Antitumor Drug.

Authors:  Sobhi M Gomha; Taher A Salaheldin; Huwaida M E Hassaneen; Hassan M Abdel-Aziz; Mohammed A Khedr
Journal:  Molecules       Date:  2015-12-22       Impact factor: 4.411

10.  Utility of 5-(furan-2-yl)-3-(p-tolyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide in the synthesis of heterocyclic compounds with antimicrobial activity.

Authors:  Abdou O Abdelhamid; Ibrahim E El Sayed; Yasser H Zaki; Ahmed M Hussein; Mangoud M Mangoud; Mona A Hosny
Journal:  BMC Chem       Date:  2019-04-01
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