Literature DB >> 10327282

Sterol regulatory element-binding proteins: activators of cholesterol and fatty acid biosynthesis.

J D Horton1, I Shimomura.   

Abstract

A family of transcription factors designated sterol regulatory element-binding proteins (SREBPs) mediates the previously described end-product feedback regulation of cholesterol biosynthesis. In addition, SREBPs are emerging as important regulators of fatty acid synthesis. The current review focuses on the in-vivo regulation of SREBPs in liver and the coordinate regulation of SREBP-activated target genes.

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Year:  1999        PMID： 10327282     DOI： 10.1097/00041433-199904000-00008

Source DB:  PubMed          Journal:  Curr Opin Lipidol        ISSN： 0957-9672            Impact factor:   4.776


  62 in total

Review 1.  Mechanisms of nutritional and hormonal regulation of lipogenesis.

Authors:  S Kersten
Journal:  EMBO Rep       Date:  2001-04       Impact factor: 8.807

Review 2.  SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver.

Authors:  Jay D Horton; Joseph L Goldstein; Michael S Brown
Journal:  J Clin Invest       Date:  2002-05       Impact factor: 14.808

3.  SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation.

Authors:  M Matsuda; B S Korn; R E Hammer; Y A Moon; R Komuro; J D Horton; J L Goldstein; M S Brown; I Shimomura
Journal:  Genes Dev       Date:  2001-05-15       Impact factor: 11.361

4.  Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta.

Authors:  J J Repa; G Liang; J Ou; Y Bashmakov; J M Lobaccaro; I Shimomura; B Shan; M S Brown; J L Goldstein; D J Mangelsdorf
Journal:  Genes Dev       Date:  2000-11-15       Impact factor: 11.361

5.  Role of LXRs in control of lipogenesis.

Authors:  J R Schultz; H Tu; A Luk; J J Repa; J C Medina; L Li; S Schwendner; S Wang; M Thoolen; D J Mangelsdorf; K D Lustig; B Shan
Journal:  Genes Dev       Date:  2000-11-15       Impact factor: 11.361

Review 6.  Fluidity of insulin action.

Authors:  Jeffrey S Elmendorf
Journal:  Mol Biotechnol       Date:  2004-06       Impact factor: 2.695

Review 7.  Regulation of cholesterol homeostasis.

Authors:  Leigh Goedeke; Carlos Fernández-Hernando
Journal:  Cell Mol Life Sci       Date:  2011-10-19       Impact factor: 9.261

8.  Classification of a large microarray data set: algorithm comparison and analysis of drug signatures.

Authors:  Georges Natsoulis; Laurent El Ghaoui; Gert R G Lanckriet; Alexander M Tolley; Fabrice Leroy; Shane Dunlea; Barrett P Eynon; Cecelia I Pearson; Stuart Tugendreich; Kurt Jarnagin
Journal:  Genome Res       Date:  2005-05       Impact factor: 9.043

9.  A large indel mutation of the bovine ADD1/SREBP1c gene and its effects on growth traits in some native cattle breeds from China.

Authors:  Yong-Zhen Huang; En-Ping Zhang; Jing Wang; Yong-Tao Huai; Liang Ma; Fu-Ying Chen; Xian-Yong Lan; Chu-Zhao Lei; Xing-Tang Fang; Ju-Qiang Wang; Hong Chen
Journal:  Mol Biol Rep       Date:  2010-09-26       Impact factor: 2.316

10.  Fibrates modify the expression of key factors involved in bile-acid synthesis and biliary-lipid secretion in gallstone patients.

Authors:  Núria Roglans; Manuel Vázquez-Carrera; Marta Alegret; Ferran Novell; Daniel Zambón; Emilio Ros; Juan C Laguna; Rosa M Sánchez
Journal:  Eur J Clin Pharmacol       Date:  2003-12-18       Impact factor: 2.953
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