Y Lu1, J Z Li, X Zheng. 1. Nephrology Institute, Beijing Medical University.
Abstract
OBJECTIVE: To confirm the renal protective action of Astragalus Angelica mixture (AAM). METHODS: Effect of AAM was observed in puromycin amino-nucleoside induced nephrotic syndrome model of rat, and pravachol, an effective lipid lowering medicine, was used as positive control. RESULTS: AAM could not only reduce the serum levels of total cholesterol and triglyceride as pravachol did, but also could lower levels of low density lipoprotein and apolipoprotein B100 (P < 0.05). Light microscopic and immuno-histochemical examination revealed that in the same time of lowering serum lipids, this mixture could also cause reduction of glomerular sclerosing index (P < 0.01) and less accumulation of extracellular matrix (P < 0.01). CONCLUSIONS: AAM has the effects of regulating lipid metabolism, attenuating renal damage and maintaining renal function in rats with nephrotic syndrome.
OBJECTIVE: To confirm the renal protective action of Astragalus Angelica mixture (AAM). METHODS: Effect of AAM was observed in puromycin amino-nucleoside induced nephrotic syndrome model of rat, and pravachol, an effective lipid lowering medicine, was used as positive control. RESULTS: AAM could not only reduce the serum levels of total cholesterol and triglyceride as pravachol did, but also could lower levels of low density lipoprotein and apolipoprotein B100 (P < 0.05). Light microscopic and immuno-histochemical examination revealed that in the same time of lowering serum lipids, this mixture could also cause reduction of glomerular sclerosing index (P < 0.01) and less accumulation of extracellular matrix (P < 0.01). CONCLUSIONS: AAM has the effects of regulating lipid metabolism, attenuating renal damage and maintaining renal function in rats with nephrotic syndrome.
Authors: Michael E Rogers; Ruth M Bohlken; Michael W Beets; Steve B Hammer; Tim N Ziegenfuss; Nejc Sarabon Journal: J Sports Sci Med Date: 2006-03-01 Impact factor: 2.988