Literature DB >> 10322485

A fly's eye view of biology.

B J Thomas1, D A Wassarman.   

Abstract

Determining how genes function in developmentally complex multicellular organisms can be a formidable task. Obstacles arise from the fact that inactivation of most genes results in subtle or undetectable phenotypic alterations, and when phenotypes are observed they are often difficult to interpret because most genes play multiple roles in development. New techniques that have been applied to studying genes in the developing Drosophila eye promise to circumvent these obstacles. The advent of these techniques combined with the existing wealth of information about cellular pattern formation in the Drosophila eye make the eye a powerful model system for deciphering the function of genes in biological processes.

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Year:  1999        PMID: 10322485     DOI: 10.1016/s0168-9525(99)01720-5

Source DB:  PubMed          Journal:  Trends Genet        ISSN: 0168-9525            Impact factor:   11.639


  21 in total

1.  Molecular analysis of Drosophila eyes absent mutants reveals features of the conserved Eya domain.

Authors:  Q T Bui; J E Zimmerman; H Liu; N M Bonini
Journal:  Genetics       Date:  2000-06       Impact factor: 4.562

2.  Persistence time of loss-of-function mutations at nonessential loci affecting eye color in Drosophila melanogaster.

Authors:  Lev Y Yampolsky; Chenoa Allen; Svetlana A Shabalina; Alexey S Kondrashov
Journal:  Genetics       Date:  2005-08-22       Impact factor: 4.562

3.  Physical modeling of cell geometric order in an epithelial tissue.

Authors:  Sascha Hilgenfeldt; Sinem Erisken; Richard W Carthew
Journal:  Proc Natl Acad Sci U S A       Date:  2008-01-11       Impact factor: 11.205

Review 4.  New approaches for studying synaptic development, function, and plasticity using Drosophila as a model system.

Authors:  C Andrew Frank; Xinnan Wang; Catherine A Collins; Avital A Rodal; Quan Yuan; Patrik Verstreken; Dion K Dickman
Journal:  J Neurosci       Date:  2013-11-06       Impact factor: 6.167

5.  Loss of Drosophila melanogaster p21-activated kinase 3 suppresses defects in synapse structure and function caused by spastin mutations.

Authors:  Emily F Ozdowski; Sophia Gayle; Hong Bao; Bing Zhang; Nina T Sherwood
Journal:  Genetics       Date:  2011-07-29       Impact factor: 4.562

6.  A genetic screen supports a broad role for the Drosophila insulator proteins BEAF-32A and BEAF-32B in maintaining patterns of gene expression.

Authors:  Swarnava Roy; Yian Yee Tan; Craig M Hart
Journal:  Mol Genet Genomics       Date:  2006-12-02       Impact factor: 3.291

7.  NCBP2 modulates neurodevelopmental defects of the 3q29 deletion in Drosophila and Xenopus laevis models.

Authors:  Mayanglambam Dhruba Singh; Matthew Jensen; Micaela Lasser; Emily Huber; Tanzeen Yusuff; Lucilla Pizzo; Brian Lifschutz; Inshya Desai; Alexis Kubina; Sneha Yennawar; Sydney Kim; Janani Iyer; Diego E Rincon-Limas; Laura Anne Lowery; Santhosh Girirajan
Journal:  PLoS Genet       Date:  2020-02-13       Impact factor: 5.917

Review 8.  Drosophila melanogaster: a model and a tool to investigate malignancy and identify new therapeutics.

Authors:  Cayetano Gonzalez
Journal:  Nat Rev Cancer       Date:  2013-02-07       Impact factor: 60.716

9.  A modifier screen in the Drosophila eye reveals that aPKC interacts with Glued during central synapse formation.

Authors:  Lisha Ma; Louise A Johns; Marcus J Allen
Journal:  BMC Genet       Date:  2009-11-30       Impact factor: 2.797

10.  A genetic screen for dominant modifiers of a cyclin E hypomorphic mutation identifies novel regulators of S-phase entry in Drosophila.

Authors:  Anthony Brumby; Julie Secombe; Julie Horsfield; Michelle Coombe; Nancy Amin; Deborah Coates; Robert Saint; Helena Richardson
Journal:  Genetics       Date:  2004-09       Impact factor: 4.562

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