Literature DB >> 10322334

The biochemical basis of arsenical-diamidine crossresistance in African trypanosomes.

M P Barrett1, A H Fairlamb.   

Abstract

Resistance to currently used drugs is a serious problem in most fields of antimicrobial chemotherapy. Crossresistance between two of the major classes of drug used in the treatment of African trypanosomiasis, the melaminophenyl arsenicals and diamidines is easily selected in the laboratory. Here, Mike Barrett and Alan Fairlamb outline the mechanism underlying this crossresistance, which appears to arise as a result of alterations in an unusual adenosine transporter involved in the uptake of these drugs.

Entities:  

Mesh：

Substances：

Year:  1999        PMID： 10322334     DOI： 10.1016/s0169-4758(99)01414-3

Source DB:  PubMed          Journal:  Parasitol Today        ISSN： 0169-4758


  27 in total

Review 1.  Current therapeutics, their problems, and sulfur-containing-amino-acid metabolism as a novel target against infections by "amitochondriate" protozoan parasites.

Authors:  Vahab Ali; Tomoyoshi Nozaki
Journal:  Clin Microbiol Rev       Date:  2007-01       Impact factor: 26.132

2.  Interaction of monobenzamidine-linked trypanocides with the Trypanosoma brucei P2 aminopurine transporter.

Authors:  Mhairi L Stewart; Cyrille Boussard; Reto Brun; Ian H Gilbert; Michael P Barrett
Journal:  Antimicrob Agents Chemother       Date:  2005-12       Impact factor: 5.191

3.  Cross-resistance to nitro drugs and implications for treatment of human African trypanosomiasis.

Authors:  Antoaneta Y Sokolova; Susan Wyllie; Stephen Patterson; Sandra L Oza; Kevin D Read; Alan H Fairlamb
Journal:  Antimicrob Agents Chemother       Date:  2010-05-03       Impact factor: 5.191

4.  Production, purification and crystallization of a trans-sialidase from Trypanosoma vivax.

Authors:  Carole L F Haynes; Paul Ameloot; Han Remaut; Nico Callewaert; Yann G J Sterckx; Stefan Magez
Journal:  Acta Crystallogr F Struct Biol Commun       Date:  2015-04-21       Impact factor: 1.056

5.  A molecular mechanism for eflornithine resistance in African trypanosomes.

Authors:  Isabel M Vincent; Darren Creek; David G Watson; Mohammed A Kamleh; Debra J Woods; Pui Ee Wong; Richard J S Burchmore; Michael P Barrett
Journal:  PLoS Pathog       Date:  2010-11-24       Impact factor: 6.823

6.  Trypanocidal activity of melamine-based nitroheterocycles.

Authors:  Mhairi L Stewart; Gorka Jimenez Bueno; Alessandro Baliani; Burkhard Klenke; Reto Brun; Janice M Brock; Ian H Gilbert; Michael P Barrett
Journal:  Antimicrob Agents Chemother       Date:  2004-05       Impact factor: 5.191

7.  The trypanocide diminazene aceturate is accumulated predominantly through the TbAT1 purine transporter: additional insights on diamidine resistance in african trypanosomes.

Authors:  Harry P de Koning; Laura F Anderson; Mhairi Stewart; Richard J S Burchmore; Lynsey J M Wallace; Michael P Barrett
Journal:  Antimicrob Agents Chemother       Date:  2004-05       Impact factor: 5.191

8.  Chemical validation of trypanothione synthetase: a potential drug target for human trypanosomiasis.

Authors:  Leah S Torrie; Susan Wyllie; Daniel Spinks; Sandra L Oza; Stephen Thompson; Justin R Harrison; Ian H Gilbert; Paul G Wyatt; Alan H Fairlamb; Julie A Frearson
Journal:  J Biol Chem       Date:  2009-10-14       Impact factor: 5.157

9.  A comparative study of methylglyoxal metabolism in trypanosomatids.

Authors:  Neil Greig; Susan Wyllie; Stephen Patterson; Alan H Fairlamb
Journal:  FEBS J       Date:  2008-12-03       Impact factor: 5.542

10.  Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methods.

Authors:  Susan Wyllie; Sandra L Oza; Stephen Patterson; Daniel Spinks; Stephen Thompson; Alan H Fairlamb
Journal:  Mol Microbiol       Date:  2009-06-24       Impact factor: 3.501
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.