| Literature DB >> 10320798 |
L S Brady1, M Herkenham, R B Rothman, J S Partilla, M König, A M Zimmer, A Zimmer.
Abstract
Mu and delta opioid receptors were labeled in enkephalin knockout mice by quantitative autoradiography. Discrete, large increases (100-300%) were found in limbic forebrain structures for mu binding and striatum and pallidum for delta binding. The up-regulation of opioid receptors may reflect a form of 'denervation supersensitivity. ' The receptor up-regulation in limbic areas is consistent with the increased emotional and aggressive behaviors observed in the enkephalin knockout mice. Copyright 1999 Elsevier Science B.V.Entities:
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Year: 1999 PMID： 10320798 DOI： 10.1016/s0169-328x(99)00090-x
Source DB: PubMed Journal: Brain Res Mol Brain Res ISSN： 0169-328X