Literature DB >> 10320474

The biochemistry and biological significance of nonhomologous DNA end joining: an essential repair process in multicellular eukaryotes.

M R Lieber1.   

Abstract

Recent progress over the past year has provided new insights into the proteins involved in nonhomologous end joining. The assembly of Ku and DNA-dependent protein kinase at DNA ends is now understood in greater detail. Murine genetic knockouts for DNA ligase IV and XRCC4 are embryonic lethal, indicating that nonhomologous end joining is essential for viability. Interestingly, neurones, in addition to lymphocytes, are particularly vulnerable to an absence of NHEJ.

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Year:  1999        PMID： 10320474     DOI： 10.1046/j.1365-2443.1999.00245.x

Source DB:  PubMed          Journal:  Genes Cells        ISSN： 1356-9597            Impact factor:   1.891


  53 in total

Review 1.  The RAG proteins in V(D)J recombination: more than just a nuclease.

Authors:  M J Sadofsky
Journal:  Nucleic Acids Res       Date:  2001-04-01       Impact factor: 16.971

2.  Ku recruits the XRCC4-ligase IV complex to DNA ends.

Authors:  S A Nick McElhinny; C M Snowden; J McCarville; D A Ramsden
Journal:  Mol Cell Biol       Date:  2000-05       Impact factor: 4.272

3.  Homologous and non-homologous recombination differentially affect DNA damage repair in mice.

Authors:  J Essers; H van Steeg; J de Wit; S M Swagemakers; M Vermeij; J H Hoeijmakers; R Kanaar
Journal:  EMBO J       Date:  2000-04-03       Impact factor: 11.598

4.  Stimulation of homologous recombination through targeted cleavage by chimeric nucleases.

Authors:  M Bibikova; D Carroll; D J Segal; J K Trautman; J Smith; Y G Kim; S Chandrasegaran
Journal:  Mol Cell Biol       Date:  2001-01       Impact factor: 4.272

5.  Response to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AX.

Authors:  H T Chen; A Bhandoola; M J Difilippantonio; J Zhu; M J Brown; X Tai; E P Rogakou; T M Brotz; W M Bonner; T Ried; A Nussenzweig
Journal:  Science       Date:  2000-12-08       Impact factor: 47.728

Review 6.  Reverse genetic studies of homologous DNA recombination using the chicken B-lymphocyte line, DT40.

Authors:  E Sonoda; C Morrison; Y M Yamashita; M Takata; S Takeda
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2001-01-29       Impact factor: 6.237

7.  p53 C-terminal interaction with DNA ends and gaps has opposing effect on specific DNA binding by the core.

Authors:  S B Zotchev; M Protopopova; G Selivanova
Journal:  Nucleic Acids Res       Date:  2000-10-15       Impact factor: 16.971

Review 8.  Rescue of arrested replication forks by homologous recombination.

Authors:  B Michel; M J Flores; E Viguera; G Grompone; M Seigneur; V Bidnenko
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-17       Impact factor: 11.205

9.  A single amino acid substitution in DNA-PKcs explains the novel phenotype of the CHO mutant, XR-C2.

Authors:  Timothy Woods; Wei Wang; Erin Convery; Abdellatif Errami; Malgorzata Z Zdzienicka; Katheryn Meek
Journal:  Nucleic Acids Res       Date:  2002-12-01       Impact factor: 16.971

10.  Rad52 and Ku bind to different DNA structures produced early in double-strand break repair.

Authors:  Dejan Ristic; Mauro Modesti; Roland Kanaar; Claire Wyman
Journal:  Nucleic Acids Res       Date:  2003-09-15       Impact factor: 16.971
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