Literature DB >> 10234819

Functional analysis of the roles of FliQ and FlhB in flagellar expression in Helicobacter pylori.

S Foynes1, N Dorrell, S J Ward, Z W Zhang, A A McColm, M J Farthing, B W Wren.   

Abstract

Expression of the two Helicobacter pylori flagellin proteins FlaA and FlaB is required for full motility and persistent infection of the gastric mucosa. The mechanisms and regulation of the biosynthesis and export of flagella in H. pylori are still poorly understood. Scrutiny of the H. pylori 26695 genome sequence revealed homologues of FliQ and FlhB. The roles of the fliQ and flhB genes in H. pylori were investigated by the construction and characterisation of defined isogenic mutants. The results indicate that these genes are involved in the flagellar expression, adhesion to and colonisation of the gastric mucosa.

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Year:  1999        PMID： 10234819     DOI： 10.1111/j.1574-6968.1999.tb13546.x

Source DB:  PubMed          Journal:  FEMS Microbiol Lett        ISSN： 0378-1097            Impact factor:   2.742


  15 in total

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2.  Helicobacter pylori FlhB function: the FlhB C-terminal homologue HP1575 acts as a "spare part" to permit flagellar export when the HP0770 FlhBCC domain is deleted.

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Journal:  J Bacteriol       Date:  2006-11       Impact factor: 3.490

3.  Genes Associated with Desiccation and Osmotic Stress in Listeria monocytogenes as Revealed by Insertional Mutagenesis.

Authors:  Patricia A Hingston; Marta J Piercey; Lisbeth Truelstrup Hansen
Journal:  Appl Environ Microbiol       Date:  2015-05-29       Impact factor: 4.792

4.  Adherence of isogenic flagellum-negative mutants of Helicobacter pylori and Helicobacter mustelae to human and ferret gastric epithelial cells.

Authors:  M Clyne; T Ocroinin; S Suerbaum; C Josenhans; B Drumm
Journal:  Infect Immun       Date:  2000-07       Impact factor: 3.441

5.  Helicobacter pylori possesses two CheY response regulators and a histidine kinase sensor, CheA, which are essential for chemotaxis and colonization of the gastric mucosa.

Authors:  S Foynes; N Dorrell; S J Ward; R A Stabler; A A McColm; A N Rycroft; B W Wren
Journal:  Infect Immun       Date:  2000-04       Impact factor: 3.441

6.  Mutational analysis of genes encoding the early flagellar components of Helicobacter pylori: evidence for transcriptional regulation of flagellin A biosynthesis.

Authors:  E Allan; N Dorrell; S Foynes; M Anyim; B W Wren
Journal:  J Bacteriol       Date:  2000-09       Impact factor: 3.490

7.  Polymorphism of flagellin A gene in Helicobacter pylori.

Authors:  W S Ji; J L Hu; J W Qiu; D R Peng; B L Shi; S J Zhou; K C Wu; D M Fan
Journal:  World J Gastroenterol       Date:  2001-12       Impact factor: 5.742

8.  Two predicted chemoreceptors of Helicobacter pylori promote stomach infection.

Authors:  Tessa M Andermann; Yu-Ting Chen; Karen M Ottemann
Journal:  Infect Immun       Date:  2002-10       Impact factor: 3.441

9.  Insertion mutations in Helicobacter pylori flhA reveal strain differences in RpoN-dependent gene expression.

Authors:  Jennifer Tsang; Todd G Smith; Lara E Pereira; Timothy R Hoover
Journal:  Microbiology       Date:  2012-11-15       Impact factor: 2.777

10.  pH-regulated gene expression of the gastric pathogen Helicobacter pylori.

Authors:  D Scott Merrell; Maria L Goodrich; Glen Otto; Lucy S Tompkins; Stanley Falkow
Journal:  Infect Immun       Date:  2003-06       Impact factor: 3.441
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