Literature DB >> 10230632

Analogues of 4,5-bis(3,5-dichlorophenyl)-2-trifluoromethyl-1H-imidazole as potential antibacterial agents.

M Antolini1, A Bozzoli, C Ghiron, G Kennedy, T Rossi, A Ursini.   

Abstract

A preliminary exploration of analogues of 4,5-bis(3,5-dichlorophenyl)-2-trifluoromethyl-1H-imidazole, 1, as novel antibacterial agents was carried out to determine the basic features of the structure responsible for the observed biological activity. The presence of two aryl rings, the imidazole NH and either a good electron withdrawing group or an aldehyde or amino group at C-2 were required for good levels of activity against methicillin resistant Staphylococcus aureus (MRSA).

Entities:  

Mesh：

Substances：

Year:  1999        PMID： 10230632     DOI： 10.1016/s0960-894x(99)00112-2

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  11 in total

Review 1.  Current advances in the synthesis and biological potencies of tri- and tetra-substituted 1H-imidazoles.

Authors:  Majid M Heravi; Mansoureh Daraie; Vahideh Zadsirjan
Journal:  Mol Divers       Date:  2015-04-12       Impact factor: 2.943

2.  2-(chromon-3-yl)imidazole derivatives as potential antimicrobial agents: synthesis, biological evaluation and molecular docking studies.

Authors:  Shweta Sharma; Vishal Sharma; Gurpreet Singh; Harpreet Kaur; Shubham Srivastava; Mohan Paul S Ishar
Journal:  J Chem Biol       Date:  2016-11-16

3.  Combretastatin A-4 derivatives: synthesis and evaluation of 2,4,5-triaryl-1H-imidazoles as potential agents against H1299 (non-small cell lung cancer cell).

Authors:  Chih-Hua Tseng; Chi-Yi Li; Chien-Chih Chiu; Huei-Ting Hu; Chein-Hwa Han; Yeh-Long Chen; Cherng-Chyi Tzeng
Journal:  Mol Divers       Date:  2012-09-26       Impact factor: 2.943

4.  Site Specific Interaction Between TiO2 Nanoparticles and Phenanthrimidazole-A First Principles Quantum Mechanical Study.

Authors:  Jayaraman Jayabharathi; Periyasamy Ramanathan; Chockalingam Karunakaran; Venugopal Thanikachalam
Journal:  J Fluoresc       Date:  2015-06-26       Impact factor: 2.217

5.  Photoinduced electron transfer from phenanthrimidazole to magnetic nanoparticles.

Authors:  J Jayabharathi; A Arunpandiyan; V Thanikachalam; P Ramanathan
Journal:  J Fluoresc       Date:  2015-01-17       Impact factor: 2.217

6.  C-H bonds as ubiquitous functionality: a general approach to complex arylated imidazoles via regioselective sequential arylation of all three C-H bonds and regioselective N-alkylation enabled by SEM-group transposition.

Authors:  Jung Min Joo; B Barry Touré; Dalibor Sames
Journal:  J Org Chem       Date:  2010-08-06       Impact factor: 4.354

7.  Wells-Dawson heteropolyacid supported on silica: a highly efficient catalyst for synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazoles.

Authors:  Ali Reza Karimi; Zahra Alimohammadi; Mostafa M Amini
Journal:  Mol Divers       Date:  2009-10-29       Impact factor: 2.943

8.  Supported heteropoly acids offering strong option for efficient and cleaner processing for the synthesis of imidazole derivatives under solvent-free condition.

Authors:  Ezzat Rafiee; Houri Mahdavi; Mohammad Joshaghani
Journal:  Mol Divers       Date:  2010-01-26       Impact factor: 2.943

9.  2-(4-Meth-oxy-phen-yl)-1-pentyl-4,5-di-phenyl-1H-imidazole.

Authors:  Jim Simpson; Shaaban K Mohamed; Adel A Marzouk; Avtandil H Talybov; Antar A Abdelhamid
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-12-05

10.  2-(4-Meth-oxy-phen-yl)-4,5-diphenyl-1-(prop-2-en-1-yl)-1H-imidazole.

Authors:  Mehmet Akkurt; Adel A Marzouk; Vagif M Abbasov; Antar A Abdelhamid; Atash V Gurbanov
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-10-13
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.