BACKGROUND/AIMS: We simultaneously conducted case-control studies, in Kerala of South India, on chronic calcific pancreatitis of the tropics (CCPT), pancreatic ductal adenocarcinoma (PDA) with CCPT, and PDA alone to assess similarity of and difference between their risk factors. METHODOLOGY: Cases with one of these diseases were identified at the Trivandrum Medical College (TMC) Hospital, in Kerala, from 1994 to 1996. Controls were selected from healthy hospital visitors of the TMC Hospital by individual age (within +/- 3 years) and sex-matched with the index case. Odds ratios and their 95% confidence intervals for potential risk factors were calculated. RESULTS: Frequent consumption of cassava was positively associated with the risk of PDA with CCPT. Heavy cigarette smoking and drinking large amounts of coffee and/or tea everyday were positively related to the risk of PDA alone. Frequent consumption of vegetables and/or fruits was correlated to the decreased risk of PDA alone. CONCLUSIONS: Risk factors as well as preventive factors seem to be different between PDA with CCPT and PDA alone. Further study is necessary, especially to clarify the prognostic factors which would induce pancreatic malignancy in patients with CCPT.
BACKGROUND/AIMS: We simultaneously conducted case-control studies, in Kerala of South India, on chronic calcific pancreatitis of the tropics (CCPT), pancreatic ductal adenocarcinoma (PDA) with CCPT, and PDA alone to assess similarity of and difference between their risk factors. METHODOLOGY: Cases with one of these diseases were identified at the Trivandrum Medical College (TMC) Hospital, in Kerala, from 1994 to 1996. Controls were selected from healthy hospital visitors of the TMC Hospital by individual age (within +/- 3 years) and sex-matched with the index case. Odds ratios and their 95% confidence intervals for potential risk factors were calculated. RESULTS: Frequent consumption of cassava was positively associated with the risk of PDA with CCPT. Heavy cigarette smoking and drinking large amounts of coffee and/or tea everyday were positively related to the risk of PDA alone. Frequent consumption of vegetables and/or fruits was correlated to the decreased risk of PDA alone. CONCLUSIONS: Risk factors as well as preventive factors seem to be different between PDA with CCPT and PDA alone. Further study is necessary, especially to clarify the prognostic factors which would induce pancreatic malignancy in patients with CCPT.
Authors: Rick J Jansen; Dennis P Robinson; Rachael Z Stolzenberg-Solomon; William R Bamlet; Mariza de Andrade; Ann L Oberg; Traci J Hammer; Kari G Rabe; Kristin E Anderson; Janet E Olson; Rashmi Sinha; Gloria M Petersen Journal: Cancer Causes Control Date: 2011-09-14 Impact factor: 2.506
Authors: Anita Koushik; Donna Spiegelman; Demetrius Albanes; Kristin E Anderson; Leslie Bernstein; Piet A van den Brandt; Leif Bergkvist; Dallas R English; Jo L Freudenheim; Charles S Fuchs; Jeanine M Genkinger; Graham G Giles; R Alexandra Goldbohm; Pamela L Horn-Ross; Satu Männistö; Marjorie L McCullough; Amy E Millen; Anthony B Miller; Kim Robien; Thomas E Rohan; Arthur Schatzkin; James M Shikany; Rachael Z Stolzenberg-Solomon; Walter C Willett; Alicja Wolk; Regina G Ziegler; Stephanie A Smith-Warner Journal: Am J Epidemiol Date: 2012-08-08 Impact factor: 4.897
Authors: Cynthia A Thomson; Kaja LeWinn; Tara R Newton; David S Alberts; Maria Elena Martinez Journal: Curr Oncol Rep Date: 2003-05 Impact factor: 5.075