Literature DB >> 10228608

Inhibitory effect of andrographolide from Andrographis paniculata on PAF-induced platelet aggregation.

E Amroyan1, E Gabrielian, A Panossian, G Wikman, H Wagner.   

Abstract

Andrographolide, an active principle of the Chinese drug Andrographis paniculata, used for prevention and treatment of common cold in Scandinavia and known as an antiinflammatory, antiviral, antithrombotic, hypotensive and antiatherosclerotic drug, was investigated for its suggested influence on the biosynthesis of eicosanoids and the platelet-activating factor (PAF). Whereas in isolated human polymorph-nuclear leukocytes (PMNL) no influence on the biosynthesis was found, it could be shown that andrographolide inhibits PAF-induced human blood platelet aggregation in a dose dependent manner (IC50-5 microM). These results indicate that andrographolide has a mechanism of action different from that of non-steroidal antiinflammatory drugs (NSAID) and most likely associated with the cardiovascular and antithrombotic activity described of Andrographis paniculata.

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Year:  1999        PMID： 10228608     DOI： 10.1016/S0944-7113(99)80031-2

Source DB:  PubMed          Journal:  Phytomedicine        ISSN： 0944-7113            Impact factor:   5.340


  28 in total

1.  Apoptosis inducing effect of andrographolide on TD-47 human breast cancer cell line.

Authors:  Harjotaruno Sukardiman; Aty Widyawaruyanti; Noor Cholies Zaini
Journal:  Afr J Tradit Complement Altern Med       Date:  2007-02-16

Review 2.  Interaction between warfarin and Chinese herbal medicines.

Authors:  Yan Ting Chua; Xiang Ling Ang; Xi Ming Zhong; Kei Siong Khoo
Journal:  Singapore Med J       Date:  2015-01       Impact factor: 1.858

3.  A novel role of andrographolide, an NF-kappa B inhibitor, on inhibition of platelet activation: the pivotal mechanisms of endothelial nitric oxide synthase/cyclic GMP.

Authors:  Wan-Jung Lu; Jie-Jen Lee; Duen-Suey Chou; Thanasekaran Jayakumar; Tsorng-Han Fong; George Hsiao; Joen-Rong Sheu
Journal:  J Mol Med (Berl)       Date:  2011-08-06       Impact factor: 4.599

4.  Andrographolide prevents oxygen radical production by human neutrophils: possible mechanism(s) involved in its anti-inflammatory effect.

Authors:  Yuh-Chiang Shen; Chieh-Fu Chen; Wen-Fei Chiou
Journal:  Br J Pharmacol       Date:  2002-01       Impact factor: 8.739

5.  The genome of the medicinal plant Andrographis paniculata provides insight into the biosynthesis of the bioactive diterpenoid neoandrographolide.

Authors:  Wei Sun; Liang Leng; Qinggang Yin; MeiMei Xu; Mingkun Huang; Zhichao Xu; Yujun Zhang; Hui Yao; Caixia Wang; Chao Xiong; Sha Chen; Chunhong Jiang; Ning Xie; Xilong Zheng; Ying Wang; Chi Song; Reuben J Peters; Shilin Chen
Journal:  Plant J       Date:  2019-01-02       Impact factor: 6.417

6.  Insights into the antiatherogenic molecular mechanisms of andrographolide against Porphyromonas gingivalis-induced atherosclerosis in rabbits.

Authors:  Rami Al Batran; Fouad Al-Bayaty; Mazen M Jamil Al-Obaidi; Amer Ashrafi
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2014-08-30       Impact factor: 3.000

Review 7.  Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress- and aging-related diseases.

Authors:  Alexander G Panossian; Thomas Efferth; Alexander N Shikov; Olga N Pozharitskaya; Kenny Kuchta; Pulok K Mukherjee; Subhadip Banerjee; Michael Heinrich; Wanying Wu; De-An Guo; Hildebert Wagner
Journal:  Med Res Rev       Date:  2020-10-25       Impact factor: 12.944

8.  Andrographolide protects against LPS-induced acute lung injury by inactivation of NF-κB.

Authors:  Tao Zhu; Dao-xin Wang; Wei Zhang; Xiu-qing Liao; Xian Guan; Hong Bo; Jia-yang Sun; Ni-wen Huang; Jing He; Yun-kun Zhang; Jing Tong; Chang-yi Li
Journal:  PLoS One       Date:  2013-02-21       Impact factor: 3.240

9.  A biochemical study on the gastroprotective effect of andrographolide in rats induced with gastric ulcer.

Authors:  P Saranya; A Geetha; S M K Narmadha Selvamathy
Journal:  Indian J Pharm Sci       Date:  2011-09       Impact factor: 0.975

10.  Experimental and Clinical Pharmacology of Andrographis paniculata and Its Major Bioactive Phytoconstituent Andrographolide.

Authors:  Thanasekaran Jayakumar; Cheng-Ying Hsieh; Jie-Jen Lee; Joen-Rong Sheu
Journal:  Evid Based Complement Alternat Med       Date:  2013-03-24       Impact factor: 2.629
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