Literature DB >> 20161898

Apoptosis inducing effect of andrographolide on TD-47 human breast cancer cell line.

Harjotaruno Sukardiman1, Aty Widyawaruyanti, Noor Cholies Zaini.   

Abstract

Andrographolide isolated from Andrographis paniculata Ness (Acanthaceae) at 0.35 mM, 0.70 mM and 1.40 mM induced DNA fragmentation and increased the percentage of apoptotic cells when TD-47 human breast cancer cell line was treated for 24, 48 and 72 h. The results demonstrated that andrographolide can induce apoptosis in TD-47 human breast cancer cell line in a time and concentration-dependent manner by increase expression of p53, bax, caspase-3 and decrease expression of bcl-2 determined by immunohistochemical analysis.

Entities:  

Keywords:  Andrographis paniculata Ness; TD-47 cell; andrographolide; apoptosis

Year:  2007        PMID： 20161898      PMCID： PMC2816486          DOI： 10.4314/ajtcam.v4i3.31228

Source DB:  PubMed          Journal:  Afr J Tradit Complement Altern Med        ISSN： 2505-0044


  29 in total

1.  Efficacy of Andrographis paniculata, Nees for pharyngotonsillitis in adults.

Authors:  V Thamlikitkul; T Dechatiwongse; S Theerapong; C Chantrakul; P Boonroj; W Punkrut; W Ekpalakorn; N Boontaeng; S Taechaiya; S Petcharoen
Journal:  J Med Assoc Thai       Date:  1991-10

2.  Hypotensive activity of aqueous extract of Andrographis paniculata in rats.

Authors:  C Y Zhang; B K Tan
Journal:  Clin Exp Pharmacol Physiol       Date:  1996-08       Impact factor: 2.557

3.  Hypoglycaemic effects of Andrographis paniculata Nees on non-diabetic rabbits.

Authors:  M Borhanuddin; M Shamsuzzoha; A H Hussain
Journal:  Bangladesh Med Res Counc Bull       Date:  1994-04

4.  Sodium butyrate induces P53-independent, Fas-mediated apoptosis in MCF-7 human breast cancer cells.

Authors:  Valérie Chopin; Robert-Alain Toillon; Nathalie Jouy; Xuefen Le Bourhis
Journal:  Br J Pharmacol       Date:  2002-01       Impact factor: 8.739

Review 5.  BCL-2 family proteins: regulators of cell death involved in the pathogenesis of cancer and resistance to therapy.

Authors:  J C Reed; T Miyashita; S Takayama; H G Wang; T Sato; S Krajewski; C Aimé-Sempé; S Bodrug; S Kitada; M Hanada
Journal:  J Cell Biochem       Date:  1996-01       Impact factor: 4.429

6.  Anticancer and immunostimulatory compounds from Andrographis paniculata.

Authors:  R Ajaya Kumar; K Sridevi; N Vijaya Kumar; S Nanduri; S Rajagopal
Journal:  J Ethnopharmacol       Date:  2004-06       Impact factor: 4.360

7.  Butyrate rapidly induces growth inhibition and differentiation in HT-29 cells.

Authors:  J A Barnard; G Warwick
Journal:  Cell Growth Differ       Date:  1993-06

8.  Andrographolide and kalmegh (Andrographis paniculata) extract: in vivo and in vitro effect on hepatic lipid peroxidation.

Authors:  B R Choudhury; M K Poddar
Journal:  Methods Find Exp Clin Pharmacol       Date:  1984-09

9.  Prevention of atherosclerotic arterial stenosis and restenosis after angioplasty with Andrographis paniculata nees and fish oil. Experimental studies of effects and mechanisms.

Authors:  D W Wang; H Y Zhao
Journal:  Chin Med J (Engl)       Date:  1994-06       Impact factor: 2.628

10.  DRF 3188 a novel semi-synthetic analog of andrographolide: cellular response to MCF 7 breast cancer cells.

Authors:  Chitkala Satyanarayana; Dhanavanthri S Deevi; R Rajagopalan; Nanduri Srinivas; Sriram Rajagopal
Journal:  BMC Cancer       Date:  2004-06-18       Impact factor: 4.430
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  10 in total

1.  Identification of novel anti-inflammatory agents from Ayurvedic medicine for prevention of chronic diseases: "reverse pharmacology" and "bedside to bench" approach.

Authors:  Bharat B Aggarwal; Sahdeo Prasad; Simone Reuter; Ramaswamy Kannappan; Vivek R Yadev; Byoungduck Park; Ji Hye Kim; Subash C Gupta; Kanokkarn Phromnoi; Chitra Sundaram; Seema Prasad; Madan M Chaturvedi; Bokyung Sung
Journal:  Curr Drug Targets       Date:  2011-10       Impact factor: 3.465

2.  Andrographolide Exhibits Anticancer Activity against Breast Cancer Cells (MCF-7 and MDA-MB-231 Cells) through Suppressing Cell Proliferation and Inducing Cell Apoptosis via Inactivation of ER-α Receptor and PI3K/AKT/mTOR Signaling.

Authors:  Ruhainee Tohkayomatee; Somrudee Reabroi; Duangjai Tungmunnithum; Warisara Parichatikanond; Darawan Pinthong
Journal:  Molecules       Date:  2022-05-31       Impact factor: 4.927

3.  Cytotoxicity and cell cycle arrest induced by andrographolide lead to programmed cell death of MDA-MB-231 breast cancer cell line.

Authors:  Malabika Banerjee; Subrata Chattopadhyay; Tathagata Choudhuri; Rammohan Bera; Sanjay Kumar; Biswajit Chakraborty; Samir Kumar Mukherjee
Journal:  J Biomed Sci       Date:  2016-04-16       Impact factor: 8.410

4.  Increased reactive oxygen species levels cause ER stress and cytotoxicity in andrographolide treated colon cancer cells.

Authors:  Aditi Banerjee; Vivekjyoti Banerjee; Steven Czinn; Thomas Blanchard
Journal:  Oncotarget       Date:  2017-04-18

Review 5.  Andrographolide is an Alternative Treatment to Overcome Resistance in ER-Positive Breast Cancer via Cholesterol Biosynthesis Pathway.

Authors:  Harishini Rajaratinam; Siti Norasikin Mohd Nafi
Journal:  Malays J Med Sci       Date:  2019-11-04

6.  Andrographolide Suppresses the Growth and Metastasis of Luminal-Like Breast Cancer by Inhibiting the NF-κB/miR-21-5p/PDCD4 Signaling Pathway.

Authors:  Junchen Li; Lixun Huang; Zinan He; Minggui Chen; Yi Ding; Yuying Yao; Youfa Duan; Li Zixuan; Cuiling Qi; Lingyun Zheng; Jiangchao Li; Rongxin Zhang; Xiaoming Li; Jianwei Dai; Lijing Wang; Qian-Qian Zhang
Journal:  Front Cell Dev Biol       Date:  2021-06-23

7.  Taxifolin enhances andrographolide-induced mitotic arrest and apoptosis in human prostate cancer cells via spindle assembly checkpoint activation.

Authors:  Zhong Rong Zhang; Mazen Al Zaharna; Matthew Man-Kin Wong; Sung-Kay Chiu; Hon-Yeung Cheung
Journal:  PLoS One       Date:  2013-01-28       Impact factor: 3.240

8.  Andrographolide: a new plant-derived antineoplastic entity on horizon.

Authors:  Astha Varma; Harish Padh; Neeta Shrivastava
Journal:  Evid Based Complement Alternat Med       Date:  2011-02-10       Impact factor: 2.629

Review 9.  Andrographis paniculata (Burm. f.) Wall. ex Nees: a review of ethnobotany, phytochemistry, and pharmacology.

Authors:  Md Sanower Hossain; Zannat Urbi; Abubakar Sule; K M Hafizur Rahman
Journal:  ScientificWorldJournal       Date:  2014-12-24

10.  Andrographolide Suppresses MV4-11 Cell Proliferation through the Inhibition of FLT3 Signaling, Fatty Acid Synthesis and Cellular Iron Uptake.

Authors:  Xiao Chen; Jianbin Zhang; Lixia Yuan; Yifei Lay; Yin Kwan Wong; Teck Kwang Lim; Chye Sun Ong; Qingsong Lin; Jigang Wang; Zichun Hua
Journal:  Molecules       Date:  2017-08-31       Impact factor: 4.411
  10 in total

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