| Literature DB >> 10225942 |
M Jevon1, C Guo, B Ma, N Mordan, S P Nair, M Harris, B Henderson, G Bentley, S Meghji.
Abstract
Staphylococcus aureus is an important bone pathogen, and evidence shows that this organism is internalized by chick osteoblasts. Here we report that S. aureus is internalized by human osteoblasts. Internalization was inhibited by monodansylcadaverine and cytochalasin D and to a lesser extent by ouabain, monensin, colchicine, and nocodazole. We propose that internalization occurs via a receptor-mediated pathway, requiring the participation of cytoskeletal elements, principally actin.Entities:
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Year: 1999 PMID: 10225942 PMCID: PMC116025
Source DB: PubMed Journal: Infect Immun ISSN: 0019-9567 Impact factor: 3.441