Literature DB >> 10223958

In vitro activities of antibiotics alone and in combination against Brucella melitensis at neutral and acidic pHs.

M Akova1, D Gür, D M Livermore, T Kocagöz, H E Akalin.   

Abstract

Brucellae survive acidic pHs in phagolysosomes. Azithromycin, streptomycin, and quinolones were active against Brucella melitensis at pH 7.0 but not at pH 5.0; rifampin and doxycycline retained activity at pH 5.0. Regardless of pH, azithromycin-rifampin and ofloxacin-rifampin showed less synergy than established streptomycin-doxycycline and rifampin-doxycycline combinations.

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Year:  1999        PMID： 10223958      PMCID： PMC89265     

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  11 in total

1.  Lack of effective bactericidal activity of new quinolones against Brucella spp.

Authors:  J A García-Rodriguez; J E García Sánchez; I Trujillano
Journal:  Antimicrob Agents Chemother       Date:  1991-04       Impact factor: 5.191

2.  Quinolones for the treatment of brucellosis.

Authors:  R Lang; E Rubinstein
Journal:  J Antimicrob Chemother       Date:  1992-04       Impact factor: 5.790

3.  Efficacy of ciprofloxacin for treatment of Brucella melitensis infections.

Authors:  M B al-Sibai; M A Halim; M M el-Shaker; B A Khan; S M Qadri
Journal:  Antimicrob Agents Chemother       Date:  1992-01       Impact factor: 5.191

Review 4.  The biogenesis of lysosomes.

Authors:  S Kornfeld; I Mellman
Journal:  Annu Rev Cell Biol       Date:  1989

5.  Synergistic interactions of ciprofloxacin and extended-spectrum beta-lactams or aminoglycosides against multiply drug-resistant Pseudomonas maltophilia.

Authors:  A W Chow; J Wong; K H Bartlett
Journal:  Antimicrob Agents Chemother       Date:  1988-05       Impact factor: 5.191

6.  Interaction of aminoglycosides and cephalosporins against Pseudomonas aeruginosa. Correlation between interaction index and killing curve.

Authors:  E J Perea; E Clavijo; M C Nogales; I G García Luque
Journal:  J Antimicrob Chemother       Date:  1988-08       Impact factor: 5.790

7.  Antibacterial activity of azithromycin against Brucella melitensis.

Authors:  S M Qadri; M A Halim; Y Ueno; F M Abumustafa; A G Postle
Journal:  Chemotherapy       Date:  1995 Jul-Aug       Impact factor: 2.544

Review 8.  An overview of human brucellosis.

Authors:  E J Young
Journal:  Clin Infect Dis       Date:  1995-08       Impact factor: 9.079

9.  Quinolones in treatment of human brucellosis: comparative trial of ofloxacin-rifampin versus doxycycline-rifampin.

Authors:  M Akova; O Uzun; H E Akalin; M Hayran; S Unal; D Gür
Journal:  Antimicrob Agents Chemother       Date:  1993-09       Impact factor: 5.191

10.  Comparative activity of azithromycin and doxycycline against Brucella spp. infection in mice.

Authors:  S Domingo; I Gastearena; A I Vitas; I López-Goñi; C Dios-Viéitez; R Díaz; C Gamazo
Journal:  J Antimicrob Chemother       Date:  1995-10       Impact factor: 5.790
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  22 in total

1.  Comparison of E test to microdilution for determining in vitro activities of antibiotics against Brucella melitensis.

Authors:  D Gür; S Kocagöz; M Akova; S Unal
Journal:  Antimicrob Agents Chemother       Date:  1999-09       Impact factor: 5.191

Review 2.  Use of aminoglycosides in treatment of infections due to intracellular bacteria.

Authors:  M Maurin; D Raoult
Journal:  Antimicrob Agents Chemother       Date:  2001-11       Impact factor: 5.191

Review 3.  Quinolones for treatment of human brucellosis: critical review of the evidence from microbiological and clinical studies.

Authors:  Matthew E Falagas; Ioannis A Bliziotis
Journal:  Antimicrob Agents Chemother       Date:  2006-01       Impact factor: 5.191

4.  Activity of the investigational fluoroquinolone finafloxacin against ciprofloxacin-sensitive and -resistant Acinetobacter baumannii isolates.

Authors:  Paul G Higgins; Will Stubbings; Hilmar Wisplinghoff; Harald Seifert
Journal:  Antimicrob Agents Chemother       Date:  2010-01-25       Impact factor: 5.191

Review 5.  The current therapeutical strategies in human brucellosis.

Authors:  Mile Bosilkovski; Fariba Keramat; Jurica Arapović
Journal:  Infection       Date:  2021-03-01       Impact factor: 3.553

Review 6.  Potential new fluoroquinolone treatments for suspected bacterial keratitis.

Authors:  Rose Herbert; Mary Caddick; Tobi Somerville; Keri McLean; Shakeel Herwitker; Timothy Neal; Gabriela Czanner; Stephen Tuft; Stephen B Kaye
Journal:  BMJ Open Ophthalmol       Date:  2022-07

Review 7.  Versatility of aminoglycosides and prospects for their future.

Authors:  Sergei B Vakulenko; Shahriar Mobashery
Journal:  Clin Microbiol Rev       Date:  2003-07       Impact factor: 26.132

8.  Source of phosphate in the enzymic reaction as a point of distinction among aminoglycoside 2''-phosphotransferases.

Authors:  Marta Toth; Joseph W Chow; Shahriar Mobashery; Sergei B Vakulenko
Journal:  J Biol Chem       Date:  2009-01-21       Impact factor: 5.157

9.  Effect of carbon dioxide on broth microdilution susceptibility testing of Brucella spp.

Authors:  David R Lonsway; Laura A Jevitt; James R Uhl; Franklin R Cockerill; Mary E Anderson; Maureen M Sullivan; Barun K De; Jonathan R Edwards; Jean B Patel
Journal:  J Clin Microbiol       Date:  2009-12-23       Impact factor: 5.948

10.  Antimicrobial susceptibilities of Brucella isolates from various clinical specimens.

Authors:  Yasemin Bayram; Hanifi Korkoca; Cenk Aypak; Mehmet Parlak; Aytekin Cikman; Selcuk Kilic; Mustafa Berktas
Journal:  Int J Med Sci       Date:  2011-03-03       Impact factor: 3.738
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