| Literature DB >> 10220871 |
M W Sawicki1, N Li, D Ghosh.
Abstract
3-Hydroxyestra-1,3,5(10),7-tetraen-17-one, C18H20O2, crystallizes in space group P2(1)2(1)2(1) from ethyl acetate. The planarity of the B ring, and the difference in puckering of the C and D rings from that of estrone, are due to the presence of the C7 = C8 double bond, which may explain its function as an inhibitor of human type 1 17 beta-hydroxysteroid dehydrogenase, instead of being its substrate.Entities:
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Year: 1999 PMID： 10220871 DOI： 10.1107/s0108270198013250
Source DB: PubMed Journal: Acta Crystallogr C ISSN： 0108-2701 Impact factor: 1.172