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Literature DB >> 10217831

Apoptosis: an innate immune response to virus infection.

Abstract

Viruses can induce apoptosis of infected cells either directly, to assist virus dissemination, or by inadvertently triggering cellular sensors that initiate cell death. Cellular checkpoints that can function as 'alarm bells' to transmit pro-apoptotic signals in response to virus infections include death receptors, protein kinase R, mitochondrial membrane potential, p53 and the endoplasmic reticulum.

Entities: Disease Gene

Mesh：

Substances：
Viral Proteins

Year: 1999 PMID： 10217831 DOI： 10.1016/s0966-842x(99)01487-0

Source DB: PubMed Journal: Trends Microbiol ISSN： 0966-842X Impact factor: 17.079

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Cited

129 in total

Review 1. A portrait of the Bcl-2 protein family: life, death, and the whole picture.

Authors: M Pellegrini; A Strasser
Journal: J Clin Immunol Date: 1999-11 Impact factor: 8.317

2. Role for p53 in gene induction by double-stranded RNA.

Authors: B T Hummer; X L Li; B A Hassel
Journal: J Virol Date: 2001-08 Impact factor: 5.103

3. Overexpression of 7a, a protein specifically encoded by the severe acute respiratory syndrome coronavirus, induces apoptosis via a caspase-dependent pathway.

Authors: Yee-Joo Tan; Burtram C Fielding; Phuay-Yee Goh; Shuo Shen; Timothy H P Tan; Seng Gee Lim; Wanjin Hong
Journal: J Virol Date: 2004-12 Impact factor: 5.103

Apoptosis: an innate immune response to virus infection.

Review 1. A portrait of the Bcl-2 protein family: life, death, and the whole picture.

2. Role for p53 in gene induction by double-stranded RNA.

3. Overexpression of 7a, a protein specifically encoded by the severe acute respiratory syndrome coronavirus, induces apoptosis via a caspase-dependent pathway.

Review 4. The response of mammalian cells to double-stranded RNA.

Review 5. Viral subversion of apoptotic enzymes: escape from death row.

6. Rubella virus capsid associates with host cell protein p32 and localizes to mitochondria.

7. A novel Bcl-2-like inhibitor of apoptosis is encoded by the parapoxvirus ORF virus.

8. Down-regulation of p53 by double-stranded RNA modulates the antiviral response.

9. Swine acute diarrhea syndrome coronavirus-induced apoptosis is caspase- and cyclophilin D- dependent.

10. JC virus induces nonapoptotic cell death of human central nervous system progenitor cell-derived astrocytes.