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Literature DB >> 10213693

Male homosexuality: absence of linkage to microsatellite markers at Xq28.

Abstract

Several lines of evidence have implicated genetic factors in homosexuality. The most compelling observation has been the report of genetic linkage of male homosexuality to microsatellite markers on the X chromosome. This observation warranted further study and confirmation. Sharing of alleles at position Xq28 was studied in 52 gay male sibling pairs from Canadian families. Four markers at Xq28 were analyzed (DXS1113, BGN, Factor 8, and DXS1108). Allele and haplotype sharing for these markers was not increased over expectation. These results do not support an X-linked gene underlying male homosexuality.

Entities: Gene

Mesh：

Year: 1999 PMID： 10213693 DOI： 10.1126/science.284.5414.665

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

19 in total

1. A genomewide scan of male sexual orientation.

Authors: Brian S Mustanski; Michael G Dupree; Caroline M Nievergelt; Sven Bocklandt; Nicholas J Schork; Dean H Hamer
Journal: Hum Genet Date: 2005-01-12 Impact factor: 4.132

2. Genetic models of homosexuality: generating testable predictions.

Authors: Sergey Gavrilets; William R Rice
Journal: Proc Biol Sci Date: 2006-12-22 Impact factor: 5.349

3. Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior.

Authors: Andrea Ganna; Karin J H Verweij; John R B Perry; Benjamin M Neale; Brendan P Zietsch; Michel G Nivard; Robert Maier; Robbee Wedow; Alexander S Busch; Abdel Abdellaoui; Shengru Guo; J Fah Sathirapongsasuti; Paul Lichtenstein; Sebastian Lundström; Niklas Långström; Adam Auton; Kathleen Mullan Harris; Gary W Beecham; Eden R Martin; Alan R Sanders
Journal: Science Date: 2019-08-30 Impact factor: 47.728

10. White Americans' Genetic Lay Theories of Race Differences and Sexual Orientation: Their Relationship with Prejudice toward Blacks, and Gay Men and Lesbians.

Authors: Toby Epstein Jayaratne; Oscar Ybarra; Jane P Sheldon; Tony N Brown; Merle Feldbaum; Carla Pfeffer; Elizabeth M Petty
Journal: Group Process Intergroup Relat Date: 2006-01

Male homosexuality: absence of linkage to microsatellite markers at Xq28.

1. A genomewide scan of male sexual orientation.

2. Genetic models of homosexuality: generating testable predictions.

3. Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior.

Review 4. Human homosexuality: a paradigmatic arena for sexually antagonistic selection?

5. Excess of counterclockwise scalp hair-whorl rotation in homosexual men.

Review 6. Genetic essentialism: on the deceptive determinism of DNA.

Review 7. Minireview: Hormones and human sexual orientation.

Review 8. Neurobiology of gender identity and sexual orientation.

9. Serotonin signaling in the brain of adult female mice is required for sexual preference.

10. White Americans' Genetic Lay Theories of Race Differences and Sexual Orientation: Their Relationship with Prejudice toward Blacks, and Gay Men and Lesbians.