UNLABELLED: The objective of this study was to perform the dosimetry of 131I-labeled 81C6 monoclonal antibody (MAb) in patients with recurrent malignant brain tumors, treated by direct injections of MAb into surgically created resection cavities (SCRCs). METHODS: Absorbed dose estimates were performed for nine patients. Dosimetry was performed retrospectively using probe counts (during patient isolation) and whole-body and SPECT images thereafter. Absorbed doses were calculated for the SCRC interface and for regions of interest (ROIs) 1 and 2 cm thick, measured from the margins of cavity interface. Also, mean absorbed doses were calculated for normal brain, liver, spleen, thyroid gland, stomach, bone marrow and whole body. The average residence time for the SCRC was 111 h (65-200h). RESULTS: The average absorbed dose per unit injected activity (range) to the SCRC interface and ROIs 1 and 2 cm thick from the cavity interface were 31.9 (7.8-84.2), 1.9 (0.7-3.6) and 1.0 (0.4-1.8) cGy/MBq, respectively. Average absorbed doses per unit administered activity to brain, liver, spleen, thyroid, stomach, bone marrow and whole body were 0.18, 0.03, 0.08, 0.05, 0.02, 0.02 and 0.01 cGy/MBq, respectively. The high absorbed dose delivered to the SCRC interface may have produced an increase in cavity volume independent of tumor progression. CONCLUSION: At the maximum tolerated dose of 3700 MBq 131I-labeled 81C6 MAb, the absorbed doses to the SCRC interface and ROIs of 1 and 2 cm thickness were estimated to be 1180, 71 and 39 Gy, respectively. The estimated average absorbed dose to the brain was 6.5 Gy. There was no neurological toxicity and minimal hematologic toxicity at this maximum tolerated administration level.
UNLABELLED: The objective of this study was to perform the dosimetry of 131I-labeled 81C6 monoclonal antibody (MAb) in patients with recurrent malignant brain tumors, treated by direct injections of MAb into surgically created resection cavities (SCRCs). METHODS: Absorbed dose estimates were performed for nine patients. Dosimetry was performed retrospectively using probe counts (during patient isolation) and whole-body and SPECT images thereafter. Absorbed doses were calculated for the SCRC interface and for regions of interest (ROIs) 1 and 2 cm thick, measured from the margins of cavity interface. Also, mean absorbed doses were calculated for normal brain, liver, spleen, thyroid gland, stomach, bone marrow and whole body. The average residence time for the SCRC was 111 h (65-200h). RESULTS: The average absorbed dose per unit injected activity (range) to the SCRC interface and ROIs 1 and 2 cm thick from the cavity interface were 31.9 (7.8-84.2), 1.9 (0.7-3.6) and 1.0 (0.4-1.8) cGy/MBq, respectively. Average absorbed doses per unit administered activity to brain, liver, spleen, thyroid, stomach, bone marrow and whole body were 0.18, 0.03, 0.08, 0.05, 0.02, 0.02 and 0.01 cGy/MBq, respectively. The high absorbed dose delivered to the SCRC interface may have produced an increase in cavity volume independent of tumor progression. CONCLUSION: At the maximum tolerated dose of 3700 MBq 131I-labeled 81C6 MAb, the absorbed doses to the SCRC interface and ROIs of 1 and 2 cm thickness were estimated to be 1180, 71 and 39 Gy, respectively. The estimated average absorbed dose to the brain was 6.5 Gy. There was no neurological toxicity and minimal hematologic toxicity at this maximum tolerated administration level.
Authors: Janina Baranowska-Kortylewicz; Michio Abe; Kristian Pietras; Zbigniew P Kortylewicz; Takashi Kurizaki; Jessica Nearman; Janna Paulsson; R Lee Mosley; Charles A Enke; Arne Ostman Journal: Cancer Res Date: 2005-09-01 Impact factor: 12.701
Authors: Amerigo Boiardi; Mirco Bartolomei; Antonio Silvani; Marica Eoli; Andrea Salmaggi; Elena Lamperti; Ida Milanesi; Andrea Botturi; Paola Rocca; Lisa Bodei; Giovanni Broggi; Giovanni Paganelli Journal: J Neurooncol Date: 2005-04 Impact factor: 4.130
Authors: John H Sampson; Raghu Raghavan; Martin L Brady; James M Provenzale; James E Herndon; David Croteau; Allan H Friedman; David A Reardon; R Edward Coleman; Terence Wong; Darell D Bigner; Ira Pastan; María Inmaculada Rodríguez-Ponce; Philipp Tanner; Raj Puri; Christoph Pedain Journal: Neuro Oncol Date: 2007-04-13 Impact factor: 12.300
Authors: Stefan Kneifel; Peter Bernhardt; Helena Uusijärvi; Stephan Good; Ludwig Plasswilm; Carlos Buitrago-Téllez; Jan Müller-Brand; Helmut Mäcke; Adrian Merlo Journal: Eur J Nucl Med Mol Imaging Date: 2007-01-31 Impact factor: 9.236
Authors: David A Reardon; Michael R Zalutsky; Gamal Akabani; R Edward Coleman; Allan H Friedman; James E Herndon; Roger E McLendon; Charles N Pegram; Jennifer A Quinn; Jeremy N Rich; James J Vredenburgh; Annick Desjardins; Sridharan Guruangan; Susan Boulton; Renee H Raynor; Jeanette M Dowell; Terence Z Wong; Xiao-Guang Zhao; Henry S Friedman; Darell D Bigner Journal: Neuro Oncol Date: 2008-02-20 Impact factor: 12.300
Authors: Roger E McLendon; Gamal Akabani; Henry S Friedman; David A Reardon; Linda Cleveland; Ilkcan Cokgor; James E Herndon; Carol Wikstrand; Susan T Boulton; Allan H Friedman; Darell D Bigner; Michael R Zalutsky Journal: Nucl Med Biol Date: 2007-03-30 Impact factor: 2.408