Literature DB >> 25086372

New radiotracers for imaging of vascular targets in angiogenesis-related diseases.

Hao Hong1, Feng Chen2, Yin Zhang3, Weibo Cai4.   

Abstract

Tremendous advances over the last several decades in positron emission tomography (PET) and single photon emission computed tomography (SPECT) allow for targeted imaging of molecular and cellular events in the living systems. Angiogenesis, a multistep process regulated by the network of different angiogenic factors, has attracted world-wide interests, due to its pivotal role in the formation and progression of different diseases including cancer, cardiovascular diseases (CVD), and inflammation. In this review article, we will summarize the recent progress in PET or SPECT imaging of a wide variety of vascular targets in three major angiogenesis-related diseases: cancer, cardiovascular diseases, and inflammation. Faster drug development and patient stratification for a specific therapy will become possible with the facilitation of PET or SPECT imaging and it will be critical for the maximum benefit of patients.
Copyright © 2014 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Angiogenesis; Cancer; Cardiovascular disease; Inflammation; Positron emission tomography (PET); Single-photon emission computed tomography (SPECT)

Mesh：

Substances：

Year:  2014        PMID： 25086372      PMCID： PMC4169744          DOI： 10.1016/j.addr.2014.07.011

Source DB:  PubMed          Journal:  Adv Drug Deliv Rev        ISSN： 0169-409X            Impact factor:   15.470


  247 in total

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3.  Near-infrared optical proteolytic beacons for in vivo imaging of matrix metalloproteinase activity.

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4.  A novel model for the pre-clinical imaging of inflamed human synovial vasculature.

Authors:  Toby Garrood; Mark Blades; Dorian O Haskard; Stephen Mather; Costantino Pitzalis
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5.  Imaging tumor angiogenesis in breast cancer experimental lung metastasis with positron emission tomography, near-infrared fluorescence, and bioluminescence.

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Journal:  Angiogenesis       Date:  2013-03-08       Impact factor: 9.596

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Review 8.  Radiotracer imaging of peripheral vascular disease.

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9.  Dual-modality micro-positron emission tomography/computed tomography and near-infrared fluorescence imaging of EphB4 in orthotopic glioblastoma xenograft models.

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5.  ImmunoPET and Near-Infrared Fluorescence Imaging of Pancreatic Cancer with a Dual-Labeled Bispecific Antibody Fragment.

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Journal:  Mol Pharm       Date:  2017-03-24       Impact factor: 4.939

Review 6.  Positron emission tomography and nanotechnology: A dynamic duo for cancer theranostics.

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7.  Noninvasive brain cancer imaging with a bispecific antibody fragment, generated via click chemistry.

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8.  Dual Targeting of Tissue Factor and CD105 for Preclinical PET Imaging of Pancreatic Cancer.

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10.  A Clinical Feasibility Study to Image Angiogenesis in Patients with Arteriovenous Malformations Using 68Ga-RGD PET/CT.

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