Literature DB >> 10203800

Gene targeting and somatic cell genetics--a rebirth or a coming of age?

J M Sedivy1, A Dutriaux.   

Abstract

A number of recent advances have significantly facilitated gene targeting in somatic cells. Gene targeting can now be performed with the same ease and efficiency in somatic cells as in murine embryonic stem cells. Rigorous genetic analyses can therefore be applied for the first time to the large number of excellent human cell culture systems. These tools will be important in areas where rodent models do not adequately represent human biology.

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Year:  1999        PMID： 10203800     DOI： 10.1016/s0168-9525(98)01689-8

Source DB:  PubMed          Journal:  Trends Genet        ISSN： 0168-9525            Impact factor:   11.639


  41 in total

1.  A novel method for constructing gene-targeting vectors.

Authors:  K Akiyama; H Watanabe; S Tsukada; H Sasai
Journal:  Nucleic Acids Res       Date:  2000-08-15       Impact factor: 16.971

Review 2.  Manipulating the mammalian genome by homologous recombination.

Authors:  K M Vasquez; K Marburger; Z Intody; J H Wilson
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-17       Impact factor: 11.205

3.  A chromosomal position effect on gene targeting in human cells.

Authors:  Rafael J Yáñez; Andrew C G Porter
Journal:  Nucleic Acids Res       Date:  2002-11-15       Impact factor: 16.971

4.  Construction of long DNA molecules using long PCR-based fusion of several fragments simultaneously.

Authors:  Nikolai A Shevchuk; Anton V Bryksin; Yevgeniya A Nusinovich; Felipe C Cabello; Margaret Sutherland; Stephan Ladisch
Journal:  Nucleic Acids Res       Date:  2004-01-22       Impact factor: 16.971

5.  Facile methods for generating human somatic cell gene knockouts using recombinant adeno-associated viruses.

Authors:  Manu Kohli; Carlo Rago; Christoph Lengauer; Kenneth W Kinzler; Bert Vogelstein
Journal:  Nucleic Acids Res       Date:  2004-01-02       Impact factor: 16.971

6.  Pleiotropic defects in TCR signaling in a Vav-1-null Jurkat T-cell line.

Authors:  Youjia Cao; Erin M Janssen; Andrew W Duncan; Amnon Altman; Daniel D Billadeau; Robert T Abraham
Journal:  EMBO J       Date:  2002-09-16       Impact factor: 11.598

7.  Stability and homogeneity of transgene expression in isogenic cells.

Authors:  Weimin Liu; Yuanzhu Xiong; Manfred Gossen
Journal:  J Mol Med (Berl)       Date:  2005-11-18       Impact factor: 4.599

8.  A somatic knockout of CBF1 in a human B-cell line reveals that induction of CD21 and CCR7 by EBNA-2 is strictly CBF1 dependent and that downregulation of immunoglobulin M is partially CBF1 independent.

Authors:  Sabine Maier; Maja Santak; Anja Mantik; Kristina Grabusic; Elisabeth Kremmer; Wolfgang Hammerschmidt; Bettina Kempkes
Journal:  J Virol       Date:  2005-07       Impact factor: 5.103

9.  Enhancement of extra chromosomal recombination in somatic cells by affecting the ratio of homologous recombination (HR) to non-homologous end joining (NHEJ).

Authors:  Gretchen M Zaunbrecher; Patrick W Dunne; Bashir Mir; Matthew Breen; Jorge A Piedrahita
Journal:  Anim Biotechnol       Date:  2008       Impact factor: 2.282

10.  Hypersensitivities for acetaldehyde and other agents among cancer cells null for clinically relevant Fanconi anemia genes.

Authors:  Soma Ghosh; Surojit Sur; Sashidhar R Yerram; Carlo Rago; Anil K Bhunia; M Zulfiquer Hossain; Bogdan C Paun; Yunzhao R Ren; Christine A Iacobuzio-Donahue; Nilofer A Azad; Scott E Kern
Journal:  Am J Pathol       Date:  2013-11-06       Impact factor: 4.307
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